Department of Mechanical, Electronic and Chemical Engineering, Faculty of Technology, Art and Design, Oslo Metropolitan University, 0130 Oslo, Norway.
Department of Biomaterials, Institute of Clinical Dentistry and Oral Research Laboratory, University of Oslo, 0317 Oslo, Norway.
Int J Mol Sci. 2022 May 29;23(11):6099. doi: 10.3390/ijms23116099.
Magnesium (Mg)-based degradable alloys have attracted substantial attention for tissue engineering applications due to their biodegradability and potential for avoiding secondary removal surgeries. However, insufficient data in the existing literature regarding Mg's corrosion and gas formation after implantation have delayed its wide clinical application. Since the surface properties of degradable materials constantly change after contact with body fluid, monitoring the behaviour of Mg in phantoms or buffer solutions could provide some information about its physicochemical surface changes over time. Through surface analysis and spectroscopic analysis, we aimed to investigate the structural and functional properties of degradable disks. Since bubble formation may lead to inflammation and change pH, monitoring components related to acidosis near the cells is essential. To study the bubble formation in cell culture media, we used a newly developed Mg alloy (based on Mg, zinc, and calcium), pure Mg, and commercially available grade 2 Titanium (Ti) disks in Dulbecco's Modified Eagle Medium (DMEM) solution to observe their behaviour over ten days of immersion. Using surface analysis and the information from near-infrared spectroscopy (NIRS), we concluded on the conditions associated with the medical risks of Mg alloy disintegration. NIRS is used to investigate the degradation behaviour of Mg-based disks in the cell culture media, which is correlated with the surface analysis where possible.
镁（Mg）基可降解合金因其可生物降解性和避免二次手术移除的潜力，在组织工程应用中引起了广泛关注。然而，由于植入后镁的腐蚀和气体形成的数据在现有文献中不足，其广泛的临床应用受到了阻碍。由于可降解材料的表面特性在与体液接触后会不断变化，因此在模型或缓冲溶液中监测镁的行为可以提供一些关于其理化表面随时间变化的信息。通过表面分析和光谱分析，我们旨在研究可降解盘的结构和功能特性。由于气泡形成可能导致炎症和 pH 值变化，因此监测细胞附近与酸中毒相关的成分至关重要。为了研究细胞培养介质中的气泡形成，我们使用了一种新开发的镁合金（基于镁、锌和钙）、纯镁和市售的 2 级钛（Ti）盘在 Dulbecco 的改良 Eagle 培养基（DMEM）溶液中观察它们在浸泡十天内的行为。通过表面分析和近红外光谱（NIRS）的信息，我们得出了与镁合金分解相关的医疗风险条件。NIRS 用于研究 Mg 基盘在细胞培养基中的降解行为，尽可能与表面分析相关联。
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