Jang Albert Youngwoo, Seo Jeongduk, Park Yae Min, Shin Yong Hoon, Lee Joonpyo, Oh Pyung Chun, Kang Woong Chol, Chung Wook-Jin, Moon Jeonggeun
Division of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Korea.
Gachon Cardiovascular Research Institute, Gachon University, Incheon 21936, Korea.
J Clin Med. 2022 May 29;11(11):3064. doi: 10.3390/jcm11113064.
Blood type is reportedly correlated with the occurrence of cardiovascular diseases, presumably because of its effect on thrombogenicity. However, the relationship between blood type and thrombotic complications in atrial fibrillation (AF) remains unclear. This retrospective study analyzed the blood types of 1170 AF patients (mean age, 70 years; 58% men) who were followed up for up to 4 years. Patients with greater than mild mitral stenosis or prosthetic valves were excluded. The cohort included 305 (26%) type O, 413 (35%) type A, 333 (28%) type B, and 119 (10%) type AB patients. The primary endpoint of major adverse cerebrovascular events (MACE) occurred in 52 (4.4%) patients. When longitudinal outcomes were plotted, AB blood type patients had worse prognosis than non-AB blood type patients ( = 0.039), particularly type O blood patients ( = 0.049). Multivariate Cox regression analysis revealed that AB blood type was associated with higher MACE rates (adjusted hazard ratio, 2.01; 95% confidence interval, 1.01-4.00; = 0.048) than non-AB blood types independent of anticoagulation therapy duration or CHA2DS2-VASc score. These indicate that AF patients with AB blood type are at an increased risk of MACE compared to those with non-AB blood type independent of the duration of anticoagulation or the CHADS-VASc score.
据报道，血型与心血管疾病的发生有关，可能是因为其对血栓形成性的影响。然而，血型与心房颤动（AF）血栓并发症之间的关系仍不清楚。这项回顾性研究分析了1170例AF患者（平均年龄70岁；58%为男性）的血型，这些患者接受了长达4年的随访。排除患有重度二尖瓣狭窄或人工瓣膜的患者。该队列包括305例（26%）O型血、413例（35%）A型血、333例（28%）B型血和119例（10%）AB型血患者。52例（4.4%）患者发生了主要不良脑血管事件（MACE）这一主要终点。绘制纵向结果时，AB型血患者的预后比非AB型血患者差（P = 0.039），尤其是O型血患者（P = 0.049）。多变量Cox回归分析显示，与非AB型血相比，AB型血与更高的MACE发生率相关（调整后的风险比为2.01；95%置信区间为1.01 - 4.00；P = 0.048），与抗凝治疗持续时间或CHA2DS2 - VASc评分无关。这些表明，与非AB型血的AF患者相比，AB型血的AF患者发生MACE的风险增加，与抗凝持续时间或CHADS - VASc评分无关。
