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Catheter ablation in a geriatric case presenting idiopathic ventricular fibrillation initiated by Purkinje-related premature ventricular contractions.一例由浦肯野相关室性早搏引发特发性室颤的老年患者的导管消融治疗
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2
Combination of low-dose quinidine and verapamil for multifocal ectopic Purkinje-related premature contractions in a patient with mutation.低剂量奎尼丁与维拉帕米联合用于一名患有[具体突变名称]突变患者的多灶性浦肯野相关早搏。 （原文中mutation未明确具体内容，所以翻译时保留英文表述并添加注释说明）
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3
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本文引用的文献

1
Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: a report from the CASPER registry.短联律室颤是不明原因心搏骤停潜在病因中的一种特殊表型：来自 CASPER 登记研究的报告。
Eur Heart J. 2021 Jul 31;42(29):2827-2838. doi: 10.1093/eurheartj/ehab275.
2
A novel gain-of-function mutation in SCN5A responsible for multifocal ectopic Purkinje-related premature contractions.一个新的 SCN5A 功能获得性突变导致多灶性异位浦肯野相关的过早收缩。
Hum Mutat. 2020 Apr;41(4):850-859. doi: 10.1002/humu.23981. Epub 2020 Jan 25.
3
Idiopathic ventricular fibrillation with repetitive activity inducible within the distal Purkinje system.特发性心室颤动，在远端浦肯野系统内可诱发出重复性活动。
Heart Rhythm. 2019 Aug;16(8):1268-1272. doi: 10.1016/j.hrthm.2019.04.012. Epub 2019 Apr 10.
4
Quinidine-Responsive Polymorphic Ventricular Tachycardia in Patients With Coronary Heart Disease.冠心病患者的奎尼丁反应性多形性室性心动过速。
Circulation. 2019 May 14;139(20):2304-2314. doi: 10.1161/CIRCULATIONAHA.118.038036.
5
Multifocal Ventricular Arrhythmias Originating From the His-Purkinje System: Incidence, Characteristics, and Outcome of Catheter Ablation.多灶性室性心律失常起源于希氏-浦肯野系统：导管消融的发生率、特征和结果。
JACC Clin Electrophysiol. 2018 Sep;4(9):1248-1260. doi: 10.1016/j.jacep.2018.06.015. Epub 2018 Jul 25.
6
R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy.R222Q SCN5A 突变与可逆性室性心律失常和扩张型心肌病相关。
J Am Coll Cardiol. 2012 Oct 16;60(16):1566-73. doi: 10.1016/j.jacc.2012.05.050. Epub 2012 Sep 19.
7
Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy.多灶性异位浦肯野相关过早收缩：一种新的 SCN5A 相关心脏通道病。
J Am Coll Cardiol. 2012 Jul 10;60(2):144-56. doi: 10.1016/j.jacc.2012.02.052.
8
Characteristics of J wave-associated idiopathic ventricular fibrillation: role of drugs.J波相关特发性室颤的特征：药物的作用
Pacing Clin Electrophysiol. 2012 Aug;35(8):e226-30. doi: 10.1111/j.1540-8159.2011.03066.x. Epub 2011 Mar 21.
9
Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation.浦肯野传导系统在特发性心室颤动触发中的作用。
Lancet. 2002 Feb 23;359(9307):677-8. doi: 10.1016/S0140-6736(02)07807-8.
10
Effects of electrophysiologic-guided therapy with Class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome.ⅠA类抗心律失常药物电生理引导治疗对伴或不伴Brugada综合征的特发性室颤患者长期预后的影响
J Cardiovasc Electrophysiol. 1999 Oct;10(10):1301-12. doi: 10.1111/j.1540-8167.1999.tb00183.x.

在一例短联律室性颤动患者中，多灶性浦肯野相关早搏和电风暴被奎尼丁和维拉帕米抑制。

Multifocal Purkinje-related premature contractions and electrical storm suppressed by quinidine and verapamil in a case with short-coupled ventricular fibrillation.

作者信息

Kataoka Naoya, Nagase Satoshi, Okawa Keisuke, Aiba Takeshi, Kinugawa Koichiro, Kusano Kengo

机构信息

Second Department of Internal Medicine, University of Toyama, Toyama, Japan.

Department of Advanced Arrhythmia and Translational Medical Science, National Cerebral and Cardiovascular Center, Suita, Japan.

出版信息

J Cardiol Cases. 2021 Dec 30;25(6):338-342. doi: 10.1016/j.jccase.2021.12.002. eCollection 2022 Jun.

DOI:10.1016/j.jccase.2021.12.002
PMID:35685260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9169001/
Abstract

In some cases with idiopathic ventricular fibrillation, short-coupled premature ventricular contractions (PVCs) initiate fatal arrhythmia, which has recently been proposed as short-coupled ventricular fibrillation (SCVF). In the present case of SCVF, catheter ablation for trigger PVCs originating from the His-Purkinje system in both ventricles caused transient complete atrioventricular block, and a combination of quinidine and verapamil suppressed ventricular tachyarrhythmia. < In some cases with short-coupled ventricular fibrillation, a combination of quinidine and verapamil can suppress fatal ventricular tachyarrhythmia.>.

摘要

在某些特发性室颤病例中，短联律室性早搏（PVCs）引发致命性心律失常，最近这种情况被称为短联律室颤（SCVF）。在本SCVF病例中，对起源于双侧心室希氏 - 浦肯野系统的触发PVCs进行导管消融导致短暂完全性房室传导阻滞，奎尼丁和维拉帕米联合使用可抑制室性快速心律失常。<在某些短联律室颤病例中，奎尼丁和维拉帕米联合使用可抑制致命性室性快速心律失常。>