Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
BengBu Medical College, Bengbu, Anhui, China.
Int J Clin Pract. 2022 Feb 1;2022:7849055. doi: 10.1155/2022/7849055. eCollection 2022.
Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz-Jeghers syndrome (PJS). The aim of this study was to assess the efficacy and safety of SBE for the treatment of small bowel polyps in patients with PJS.
We conducted a single-center observational study, which included all patients diagnosed with PJS who underwent SBE for polypectomy between January 2018 and March 2021. Complete treatment was defined as the absence of polyps ≥10 mm after SBE resection. The clinical records were retrospectively reviewed.
102 patients (including 40 men and 62 women) with a mean age of 28.7 years (range 13-55 y) were enrolled in our study. The intubation depth via the oral approach of patients with a history of laparotomy was significantly shorter than that of the patients without a history of laparotomy ([241.6 ± 64.2] cm vs [280.9 ± 40.2] cm, =0.008). The maximum size of the resected polyps via anus during the second hospitalization was significantly smaller than that during the first hospitalization ([2.25 ± 1.29] cm vs [4.26 ± 3.51] cm, =0.032). For patients with total enteroscopy, the complete treatment rate was 98% (49/50). For patients without total enteroscopy, all polyps larger than 10 mm in the examined segment of small bowel were resected successfully. Complications occurred in 10 of 129 hospitalizations (delayed bleeding in 4, perforation in 3, and acute pancreatitis in 3).
SBE is effective and safe for resection of small bowel polyps in patients with PJS.
关于单气囊小肠镜（SBE）在 Peutz-Jeghers 综合征（PJS）患者中的疗效和安全性知之甚少。本研究旨在评估 SBE 治疗 PJS 患者小肠息肉的疗效和安全性。
我们进行了一项单中心观察性研究，纳入了 2018 年 1 月至 2021 年 3 月期间所有因息肉切除术而行 SBE 的 PJS 患者。完全治疗定义为 SBE 切除后不存在≥10mm 的息肉。回顾性分析临床记录。
本研究纳入了 102 例患者（包括 40 名男性和 62 名女性），平均年龄为 28.7 岁（范围 13-55 岁）。有剖腹手术史的患者经口进镜深度明显短于无剖腹手术史的患者（[241.6±64.2]cm 比 [280.9±40.2]cm，=0.008）。第二次住院时经肛门切除的最大息肉直径明显小于第一次住院时（[2.25±1.29]cm 比 [4.26±3.51]cm，=0.032）。对于行全小肠镜检查的患者，完全治疗率为 98%（49/50）。对于未行全小肠镜检查的患者，所有大于 10mm 的小肠检查段内的息肉均成功切除。129 次住院中有 10 次发生并发症（4 例迟发性出血，3 例穿孔，3 例急性胰腺炎）。
SBE 治疗 PJS 患者小肠息肉安全有效。
