Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, UAE.
College of Arts and Sciences, American University of Sharjah, Sharjah, UAE.
Hosp Pract (1995). 2022 Aug;50(3):189-195. doi: 10.1080/21548331.2022.2088183. Epub 2022 Jun 20.
Several lines of evidence suggest that SARS-CoV-2 invasion of the central nervous system leads to meningitis and encephalopathy syndromes. Additionally, chronic alcoholics were found to be at a higher risk of developing mental health problems and serious neurological manifestations, if exposed to SARS-CoV-2 infection.
Herein, we studied RNA seq data from alcoholics' brain tissue and COVID-19 patient's brain tissue to identify the common differentially expressed genes.
Overlap analysis depicted the expression of seven genes (, and ) that were significantly upregulated in both groups. Along with these, protein-protein interaction analysis revealed 10 other key molecules with strong interactions with the aforementioned genes.
Taken together with the functional effect of these genes, we suggest a strong molecular link between COVID-19-induced severities and neurological impairment in patients suffering from alcohol abuse disorder. These findings emphasize the importance of identifying chronic alcoholism as a risk factor for developing cognitive and memory impairment in COVID-19 patients.
有几项证据表明，SARS-CoV-2 入侵中枢神经系统会导致脑膜炎和脑病综合征。此外，研究发现，如果慢性酗酒者感染 SARS-CoV-2，他们患心理健康问题和严重神经系统表现的风险更高。
在此，我们研究了来自酗酒者脑组织和 COVID-19 患者脑组织的 RNA seq 数据，以鉴定常见的差异表达基因。
重叠分析显示两组中均显著上调的七个基因（、和）的表达。除此之外，蛋白质-蛋白质相互作用分析还揭示了与上述基因具有强烈相互作用的另外 10 个关键分子。
综合这些基因的功能效应，我们认为 COVID-19 引起的严重程度与患有酒精滥用障碍的患者的神经损伤之间存在很强的分子联系。这些发现强调了将慢性酗酒确定为 COVID-19 患者发生认知和记忆障碍的风险因素的重要性。
