Department of Physiology, College of Medicine, Tikrit University, Salah-Aldeen, Iraq;
Department of Physiology, College of Medicine, Tikrit University, Salah-Aldeen, Iraq.
J Popul Ther Clin Pharmacol. 2022 Apr 11;29(1):e116-e121. doi: 10.47750/jptcp.2022.900. eCollection 2022.
Several investigations have confirmed changes in lipid profiles and other markers (interleukin [IL]-6, C-reactive protein [CRP]) in women with pregnancy induced hypertension (PIH). Although, the cause an effect correlations between these lipid profiles and other markers with the PIH are yet unknown.
To study the relationship of serum lipid profile, CRP, and IL-6 with PIH.
A cross-sectional study was done on 60 pregnant women with PIH treated in the General Salah Alden Hospital in Tikrit city, Iraq, from January 2021 to April 2021. Another group of 60 pregnant women who were normal, at the same period, were selected as the control group. The average age of the participants was (27.1 ± 5.0) years. All the blood samples taken were examined for lipid profile, CRP, and IL-6.
The results statistically showed significant differences in IL-6 level and CRP. Whereas, in the Lipid profile (triglyceride [TG], low density lipoprotein cholesterol [LDL-C], high density lipoprotein [HDL]-C, total cholesterol [TC], and very low density lipoprotein cholesterol [VLDL]) were found. Also, it was found that there were significant differences in PIH patients as compared to the control group.
The findings revealed that the lipid profile was aberrant, and the amount of IL-6 protein was positively linked with blood pressure.
多项研究证实，妊娠高血压（PIH）患者的血脂谱和其他标志物（白细胞介素[IL]-6、C 反应蛋白[CRP]）发生了变化。尽管这些血脂谱和其他标志物与 PIH 之间的因果关系尚不清楚。
研究血清脂质谱、CRP 和 IL-6 与 PIH 的关系。
在 2021 年 1 月至 2021 年 4 月期间，在伊拉克提克里特市萨拉赫丁总医院对 60 名患有 PIH 的孕妇进行了一项横断面研究。另选 60 名同期正常的孕妇作为对照组。参与者的平均年龄为（27.1±5.0）岁。所有采集的血样均用于检查血脂谱、CRP 和 IL-6。
结果显示，IL-6 水平和 CRP 存在统计学差异。而在血脂谱（甘油三酯[TG]、低密度脂蛋白胆固醇[LDL-C]、高密度脂蛋白[HDL]-C、总胆固醇[TC]和极低密度脂蛋白胆固醇[VLDL]）方面也存在差异。此外，与对照组相比，PIH 患者存在显著差异。
研究结果表明，血脂谱异常，IL-6 蛋白含量与血压呈正相关。
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