State key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Bioactive Materials (Ministry of Education), Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China.
Chem Commun (Camb). 2022 Jun 30;58(53):7396-7399. doi: 10.1039/d2cc02267b.
A hybrid prodrug was synthesized to realize the combined delivery of nitric oxide and hydrogen sulfide. The NO-HS donor can release nitric oxide and hydrogen sulfide step by step in response to the endogenous enzymes β-galactosidase and carbonic anhydrase, providing potent therapeutic efficacy for heart failure post- myocardial infarction.
合成了一种杂合前药，以实现一氧化氮和硫化氢的联合递送。NO-HS 供体能响应内源性酶β-半乳糖苷酶和碳酸酐酶逐步释放一氧化氮和硫化氢，为心肌梗死后心力衰竭提供强大的治疗效果。
