Soyinka F
Curr Med Res Opin. 1987;10(6):390-6. doi: 10.1185/03007998709111108.
A study was carried out in 40 patients with various superficial fungal diseases, confirmed by culture or microscopic examination, to assess the therapeutic efficacy and local tolerability of 1% bifonazole cream. Patients with more than one clinical diagnosis at the time of entry were treated according to the number of conditions present. The cream was applied once daily to the affected areas and treatment duration varied according to persistence or resolution of the clinical signs and symptoms in the individual patient. The results were evaluated by clinical and mycological examination 3 and 14 days after the end of treatment. A cure rate of 100% was achieved in cases of pityriasis versicolor, tinea corporis and candidiasis, and 90% in patients with tinea pedis. Clinical signs and symptoms disappeared completely in all but a few patients. No side-reactions were observed in any patient, and patch tests carried out in selected patients with known allergy and those with normal skin showed no evidence of any allergic or photosensitivity reaction to bifonazole.
对40例经培养或显微镜检查确诊的各种浅表真菌病患者进行了一项研究，以评估1%联苯苄唑乳膏的治疗效果和局部耐受性。入组时患有不止一种临床诊断的患者，根据所存在病症的数量进行治疗。乳膏每天一次涂抹于患处，治疗持续时间根据个体患者临床体征和症状的持续或消退情况而有所不同。在治疗结束后3天和14天通过临床和真菌学检查对结果进行评估。花斑癣、体癣和念珠菌病患者的治愈率达到100%，足癣患者的治愈率为90%。除少数患者外，所有患者的临床体征和症状均完全消失。未观察到任何患者出现副作用，在选定的已知过敏患者和皮肤正常的患者中进行的斑贴试验显示，没有证据表明对联苯苄唑有任何过敏或光敏反应。
