Life Science Research Center, School of Life Science and Technology, Xidian University, Shaanxi, China.
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
CNS Neurosci Ther. 2022 Sep;28(9):1461-1463. doi: 10.1111/cns.13882. Epub 2022 Jun 10.
Lifelong premature ejaculation patients had altered structural and functional parameters of the hypothalamus compared with healthy controls. The patients showed increased hypothalamus-related functional connectivity in several regions one hour after dapoxetine administration. The changing trends of the brain functional connectivity after dapoxetine administration possibly provided important information about the selective serotonin reuptake inhibitor effects on the functional neural system.
与健康对照组相比，终身早泄患者的下丘脑结构和功能参数发生了改变。患者在服用达泊西汀后 1 小时，几个与下丘脑相关的区域显示出功能连接增加。达泊西汀给药后大脑功能连接的变化趋势可能为选择性 5-羟色胺再摄取抑制剂对功能神经的影响提供了重要信息。
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