Departamento de Química, Universidade Estadual de Maringá (UEM), Maringá 87030-900, Paraná, Brazil.
J Org Chem. 2022 Jul 1;87(13):8544-8550. doi: 10.1021/acs.joc.2c00657. Epub 2022 Jun 10.
A simple, efficient and highly regioselective method for the preparation of 3,4- and 4,5-disubstituted -methylpyrazoles in a one-pot procedure is reported. The methodology developed was based on the regiochemical control of the reaction of 4-acyl-1-pyrrole-2,3-diones and methylhydrazine with an influence of the addition or absence of acid and the substrate structure.
本文报道了一种在一锅法中制备 3,4-和 4,5-二取代甲基吡唑的简单、高效和高区域选择性方法。所开发的方法基于 4-酰基-1-吡咯-2,3-二酮和甲肼的反应的区域化学控制，受酸的加入或不存在以及底物结构的影响。
