School of Biomedical Sciences & Pharmacy, University of Newcastle, NSW, Australia; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
School of Biomedical Sciences & Pharmacy, University of Newcastle, NSW, Australia; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
J Neuroimmunol. 2022 Aug 15;369:577903. doi: 10.1016/j.jneuroim.2022.577903. Epub 2022 Jun 2.
Immune mediators upregulated in peripheral to central immune communication can modulate respiratory function by direct action on brainstem respiratory circuits. In this systematic review we consolidated findings from independent studies examining the relationship between peripheral and neuro- inflammation within brainstem respiratory centres. Microglia and astrocytes modulate brainstem neuroinflammation in response to peripheral immune mediators which then regulates neuronal activity and ultimately respiratory behaviours. Overall, respiratory brainstem nuclei showed increases in several key immune factors, and glia showed an increased response following peripheral inflammation. However, the functional impact of this neuroinflammation remains unclear.
外周向中枢免疫通讯中上调的免疫介质可以通过直接作用于脑干呼吸回路来调节呼吸功能。在本系统综述中，我们整合了独立研究的结果，这些研究检查了外周和神经炎症之间在脑干呼吸中心的关系。小胶质细胞和星形胶质细胞调节脑干神经炎症，以响应外周免疫介质，从而调节神经元活动，最终调节呼吸行为。总的来说，呼吸脑干核显示出几种关键免疫因子的增加，并且在周围炎症后胶质细胞显示出增加的反应。然而，这种神经炎症的功能影响尚不清楚。
