Department of Psychiatry, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, 11794, United States.
Department of Psychiatry, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, 11794, United States; Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, United States.
Psychiatry Res Neuroimaging. 2022 Aug;324:111505. doi: 10.1016/j.pscychresns.2022.111505. Epub 2022 Jun 6.
Rejection sensitivity (RS) is the heightened expectation or perception of social rejection and is a feature of many psychiatric disorders. As endogenous opioid pathways have been implicated in response to social rejection and reward, we hypothesize that RS will be negatively associated with mu opioid receptor (MOR) baseline binding and activity during rejection and acceptance stimuli. In exploratory analyses, we assessed the relationships between MOR activity and changes in mood and self-esteem before and after stimuli. Healthy participants, N = 75 (52% female), completed rejection and acceptance tasks during [C]carfentanil positron emission tomography (PET) scans. MOR activity in the amygdala, midline thalamus, anterior insula, and nucleus accumbens (NAc) was evaluated. RS was not related to MOR baseline binding potential or activity during acceptance or rejection tasks in any region. Increased MOR activity in the NAc was associated with increase in ratings of self-esteem and positive mood during the period between acceptance task administration and approximately 5 min after the task completion. Our results suggest that endogenous opioid response to social rejection is independent of RS in healthy individuals. MOR activity in the NAc was associated with increase self-esteem and positive mood after experiencing social feedback, warranting further investigation.
拒绝敏感（RS）是对社会拒绝的高度期望或感知，是许多精神疾病的特征。由于内源性阿片途径与社会拒绝和奖励反应有关，我们假设 RS 将与拒绝和接受刺激期间的 mu 阿片受体（MOR）基线结合和活性呈负相关。在探索性分析中，我们评估了 MOR 活性与刺激前后情绪和自尊变化之间的关系。健康参与者，N=75（52%女性），在[C]carfentanil 正电子发射断层扫描（PET）扫描期间完成了拒绝和接受任务。评估了杏仁核、中线丘脑、前岛叶和伏隔核（NAc）中的 MOR 活性。在任何区域，RS 与接受或拒绝任务期间的 MOR 基线结合势能或活性均无关。NAc 中的 MOR 活性增加与接受任务期间和任务完成后约 5 分钟之间的自尊和积极情绪评分增加有关。我们的结果表明，健康个体中社会拒绝的内源性阿片反应与 RS 无关。NAc 中的 MOR 活性与经历社会反馈后的自尊和积极情绪增加有关，值得进一步研究。
