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Phrenic nerve stimulation to protect the diaphragm, lung, and brain during mechanical ventilation.

作者信息

Morris Idunn S, Dres Martin, Goligher Ewan C

机构信息

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

Department of Medicine, Division of Respirology, University Health Network, Toronto, Canada.

出版信息

Intensive Care Med. 2022 Oct;48(10):1299-1301. doi: 10.1007/s00134-022-06760-8. Epub 2022 Jun 10.

DOI:10.1007/s00134-022-06760-8
PMID:35688993
Abstract
摘要

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Phrenic nerve stimulation to protect the diaphragm, lung, and brain during mechanical ventilation.在机械通气期间进行膈神经刺激以保护膈肌、肺和脑。
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Sci Rep. 2025 Jun 2;15(1):19340. doi: 10.1038/s41598-025-04352-2.
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Transvenous phrenic nerve stimulation reduces diaphragm injury during controlled mechanical ventilation in a preclinical model of ARDS.经静脉膈神经刺激可减少 ARDS 临床前模型中控制性机械通气期间的膈肌损伤。
J Appl Physiol (1985). 2024 Nov 1;137(5):1175-1181. doi: 10.1152/japplphysiol.00884.2023. Epub 2024 Sep 12.
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Phrenic Nerve Stimulation for Acute Respiratory Failure.

本文引用的文献

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Non-invasive phrenic nerve stimulation to avoid ventilator-induced diaphragm dysfunction in critical care.无创膈神经刺激避免危重症患者呼吸机相关性膈肌功能障碍。
Artif Organs. 2022 Oct;46(10):1988-1997. doi: 10.1111/aor.14244. Epub 2022 Apr 12.
2
Diaphragm neurostimulation during mechanical ventilation reduces atelectasis and transpulmonary plateau pressure, preserving lung homogeneity and [Formula: see text]/[Formula: see text].机械通气时膈神经刺激可减少肺不张和跨肺峰压,维持肺均一性和 [Formula: see text]/[Formula: see text]。
J Appl Physiol (1985). 2021 Jul 1;131(1):290-301. doi: 10.1152/japplphysiol.00119.2021. Epub 2021 Jun 10.
3
膈肌神经刺激治疗急性呼吸衰竭。
Respir Care. 2023 Nov 25;68(12):1736-1747. doi: 10.4187/respcare.11439.
4
First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study.麻醉患者的首次非侵入性膈神经和膈肌刺激:一项概念验证研究。
Intensive Care Med Exp. 2023 Apr 21;11(1):20. doi: 10.1186/s40635-023-00506-6.
5
Safety and Feasibility of Noninvasive Electromagnetic Stimulation of the Phrenic Nerves.膈神经无创电磁刺激的安全性和可行性。
Respir Care. 2023 May;68(5):602-610. doi: 10.4187/respcare.10568. Epub 2023 Mar 6.
Corrective effect of diaphragm pacing on the decrease in cardiac output induced by positive pressure mechanical ventilation in anesthetized sheep.
Respir Physiol Neurobiol. 2017 Feb;236:23-28. doi: 10.1016/j.resp.2016.10.009. Epub 2016 Nov 9.
4
Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm.心胸外科手术中膈神经间歇性刺激对人体膈肌线粒体呼吸的影响。
Crit Care Med. 2014 Feb;42(2):e152-6. doi: 10.1097/CCM.0b013e3182a63fdf.
5
Can phrenic stimulation protect the diaphragm from mechanical ventilation-induced damage?膈神经刺激能否保护膈肌免受机械通气引起的损伤?
Eur Respir J. 2013 Jul;42(1):280-3. doi: 10.1183/09031936.00045613.
6
Phrenic nerve stimulation protects against mechanical ventilation-induced diaphragm dysfunction in rats.膈神经刺激可预防大鼠机械通气所致膈肌功能障碍。
Muscle Nerve. 2013 Dec;48(6):958-62. doi: 10.1002/mus.23850. Epub 2013 Oct 25.