Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, 14068, South Korea.
Department of Otorhinolaryngology, Hospital Medicine Center, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Sci Rep. 2022 Jun 10;12(1):9554. doi: 10.1038/s41598-022-13271-5.
This study aimed to evaluate the relationship between chronic rhinosinusitis (CRS) and proton pump inhibitor (PPI) use in a Korean population. The Korea National Health Insurance Service-National Sample Cohort was assessed from 2002 to 2013. Patients with CRS (n = 7194) and control participants (n = 28,776) were matched by random order at a 1:4 ratio for age, sex, income group, region of residence, and index date. We analyzed PPI use by patients with and without CRS. ICD-10 codes defined CRS, and claim codes defined previous PPI use. Conditional logistic regression analyzed the crude and adjusted odds ratios (ORs) with 95% confidence intervals (CI). Subgroup analyses were performed according to age and sex. There was a difference in PPI prescription history and prescription duration between the CRS and control groups. The rate of CRS was higher in current (33.8% [263/778]) and past (26.3% [713/2708]) PPI users than PPI non-users (19.1% [6218/32,484], P < 0.001). The adjusted OR (aOR) of CRS with/without nasal polyps was 1.71 (95% CI 1.46-2.02, P < 0.001) and 1.28 (95% CI 1.16-1.41, P < 0.001) in current and past PPI users, respectively. Irrespective of PPI prescription days, PPI use was associated with higher CRS occurrence (aOR 1.46; 95% CI 1.26-1.69, P < 0.001) in the 30-89-day PPI user group. The subgroup analyses results were consistent. The ORs of CRS were higher in PPI users than in the controls, and consistently so in all age and sex groups.
这项研究旨在评估质子泵抑制剂 (PPI) 使用与韩国人群慢性鼻-鼻窦炎 (CRS) 之间的关系。从 2002 年至 2013 年，评估了韩国国家健康保险服务-国家样本队列。将 CRS 患者 (n=7194) 和对照组参与者 (n=28776) 按年龄、性别、收入群体、居住地区和索引日期以 1:4 的比例随机顺序进行匹配。我们分析了有和没有 CRS 的患者的 PPI 使用情况。ICD-10 编码定义了 CRS，而索赔代码定义了之前的 PPI 使用情况。条件逻辑回归分析了 95%置信区间 (CI) 的粗比值比 (OR) 和调整比值比 (aOR)。根据年龄和性别进行了亚组分析。CRS 组和对照组之间存在 PPI 处方史和处方持续时间的差异。当前 (33.8% [263/778]) 和过去 (26.3% [713/2708]) PPI 用户的 CRS 发生率高于 PPI 非使用者 (19.1% [6218/32484]，P<0.001)。有/无鼻息肉的 CRS 的调整 OR (aOR) 在当前和过去的 PPI 用户中分别为 1.71 (95%CI 1.46-2.02，P<0.001) 和 1.28 (95%CI 1.16-1.41，P<0.001)。无论 PPI 处方天数如何，在 30-89 天 PPI 用户组中，PPI 使用与更高的 CRS 发生相关 (aOR 1.46；95%CI 1.26-1.69，P<0.001)。亚组分析结果一致。与对照组相比，PPI 用户的 CRS 发生率更高，在所有年龄和性别组中均如此。
