Department of Pharmacy, Children's Hospital Colorado, Aurora, CO, USA.
Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC, USA.
J Pharm Pract. 2023 Oct;36(5):1264-1267. doi: 10.1177/08971900221107841. Epub 2022 Jun 10.
Intravenous (IV) administration of calcineurin inhibitors, cyclosporine (CsA) and tacrolimus (TAC), has been associated with spuriously high serum concentrations collected from central venous catheters (CVCs) used for medication administration, secondary to reversible adsorption of medication to the catheter. Thus, therapeutic drug monitoring of IV CsA and TAC via CVCs previously exposed to these agents should be interpreted cautiously and ideally avoided. The duration of this effect is poorly characterized and the risk for extension of this effect to unexposed lumens of the same central catheter remains uncertain. We describe a case of a pediatric patient with artificially elevated serum TAC concentrations obtained from previously exposed and unexposed lumens of a central catheter, 27 days after last IV TAC administration.
静脉内（IV）给予钙调神经磷酸酶抑制剂，环孢素（CsA）和他克莫司（TAC），与从中枢静脉导管（CVC）采集的假性高血清浓度有关，因为药物可逆地吸附到导管上。因此，通过先前暴露于这些药物的 CVC 对 IV CsA 和 TAC 进行治疗药物监测应谨慎解释，理想情况下应避免。这种影响的持续时间特征描述较差，并且相同中心导管的未暴露腔道中这种影响扩展的风险仍然不确定。我们描述了一个儿科患者的案例，该患者在最后一次 IV TAC 给药 27 天后，从先前暴露和未暴露的中央导管腔中获得了人为升高的血清 TAC 浓度。
