Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Warren Alpert Medical School of Brown University, Providence, Rhode Island.
J Am Acad Child Adolesc Psychiatry. 2022 Dec;61(12):1401-1403. doi: 10.1016/j.jaac.2022.05.007. Epub 2022 Jun 8.
Pediatric catatonia is a complex neuropsychiatric syndrome. Benzodiazepines are standard first-line pharmacotherapy. When benzodiazepines do not provide relief of symptoms, electroconvulsive therapy (ECT) is the most proven effective therapy. However, the use of NMDA antagonists (amantadine and memantine) has been reported effective in adult patients as adjuncts and may provide an alternative treatment modality when ECT is not readily accessible. To the author's knowledge there are no prior case reports of memantine used in pediatric catatonia. This case demonstrates the safe use of memantine as an adjunctive agent in an adolescent with catatonia.
儿童紧张症是一种复杂的神经精神综合征。苯二氮䓬类药物是标准的一线药物治疗。当苯二氮䓬类药物不能缓解症状时，电休克治疗（ECT）是最有效的治疗方法。然而，NMDA 拮抗剂（金刚烷胺和美金刚）已被报道在成年患者中作为辅助治疗有效，并且在 ECT 不易获得时可能提供替代治疗方式。据作者所知，以前没有金刚烷胺用于儿童紧张症的病例报告。本病例表明金刚烷胺作为辅助药物在患有紧张症的青少年中的安全使用。
