Boston Medical Center, Boston University School of Medicine, United States.
Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Epilepsy Behav. 2022 Nov;136:108769. doi: 10.1016/j.yebeh.2022.108769. Epub 2022 Jun 8.
The literature regarding breastfeeding and effects of anti-seizure medication (ASM) exposure on the breastfed infant has been evolving rapidly over the last decade as new studies advance our understanding of the extent of medication exposure via breastfeeding and the long-term developmental outcomes of breastfed infants. Currently, strong evidence supports the safety of breastfeeding for women with epilepsy (WWE) taking most prescribed ASMs. In this review, we present a comprehensive overview of the data regarding ASM exposure in breastfed infants and neurodevelopmental outcomes in breastfed infants of mothers taking various ASMs. In addition, we present current breastfeeding recommendations and the reported adverse effects of various ASMs to facilitate decision making in the clinical care of WWE.
关于母乳喂养和抗癫痫药物（ASM）暴露对母乳喂养婴儿的影响的文献在过去十年中迅速发展，新的研究加深了我们对通过母乳喂养药物暴露程度以及母乳喂养婴儿长期发育结果的理解。目前，有强有力的证据支持大多数处方 ASM 治疗的癫痫妇女（WWE）进行母乳喂养是安全的。在这篇综述中，我们全面概述了关于母乳喂养婴儿中 ASM 暴露和服用各种 ASM 的母亲的母乳喂养婴儿神经发育结果的数据。此外，我们还提出了目前的母乳喂养建议和各种 ASM 的报告不良反应，以促进 WWE 临床护理中的决策制定。
