Department of Pediatric Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812, Poznan, Poland.
Department of Clinical Auxology and Pediatric Nursing, Department of Pediatric Diabetes, Auxology and Obesity, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572, Poznan, Poland.
Clin Oral Investig. 2022 Oct;26(10):6165-6175. doi: 10.1007/s00784-022-04566-y. Epub 2022 Jun 11.
The aim of the study was to evaluate the dental and bone age delay and occlusal traits of children with growth hormone deficiency (GHD) and idiopathic short stature (ISS).
The study group included 46 patients aged 5 to 14 years: 15 with ISS, 17 with GHD before growth hormone treatment, and 14 with GHD during substitution therapy. The control group consisted of 46 age and sex-matched subjects of normal height. A calibrated dentist assessed all subjects in terms of dental age and occlusal characteristics. Bone age was evaluated only in GHD and ISS children as a part of a hospital's diagnostic protocol.
The subgroup of GHD before treatment differed significantly concerning dental age delay from their healthy peers (- 0.34 and 0.83 year, respectively, p = 0.039). Dental age delay in short stature children was less marked than bone age delay (- 0.12 and - 1.76, respectively, p < 0.00001). Dental crowding was recorded in 57% of ISS patients and 53% of GHD children before treatment compared to only 22% of the control subjects (p = 0.027 and p = 0.021, respectively).
Dental age was retarded in GHD children before growth hormone (GH) therapy, but the delay does not seem clinically significant. ISS children and GHD children before therapy showed marked bone age delay and tendency to crowding.
The different pace of teeth eruption and skeletal growth in short stature children should be considered when planning their dental treatment.
本研究旨在评估生长激素缺乏症（GHD）和特发性身材矮小症（ISS）儿童的牙齿和骨骼发育迟缓以及咬合特征。
研究组包括 46 名年龄在 5 至 14 岁的儿童：15 名 ISS 患者，17 名生长激素治疗前 GHD 患者和 14 名生长激素替代治疗中 GHD 患者。对照组由 46 名年龄和性别匹配的正常身高儿童组成。一位经过校准的牙医根据牙齿年龄和咬合特征对所有受试者进行评估。仅对 GHD 和 ISS 儿童进行骨骼年龄评估，作为医院诊断方案的一部分。
治疗前 GHD 亚组的牙齿年龄延迟与健康同龄人相比差异显著（分别为-0.34 和 0.83 岁，p=0.039）。矮小症儿童的牙齿发育迟缓程度轻于骨骼年龄发育迟缓（分别为-0.12 和-1.76，p<0.00001）。与对照组的 22%相比，ISS 患者中有 57%和治疗前 GHD 儿童中有 53%存在牙齿拥挤（p=0.027 和 p=0.021）。
生长激素治疗前 GHD 儿童的牙齿年龄延迟，但这种延迟似乎在临床上并不显著。ISS 儿童和治疗前 GHD 儿童均表现出明显的骨骼发育迟缓及拥挤倾向。
在规划矮小症儿童的牙科治疗时，应考虑牙齿萌出和骨骼生长的不同速度。
