Funatsu Minayo, Sato Koshi, Mitani Hideo
Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry Tohoku University, Sendai, Japan.
Angle Orthod. 2006 Nov;76(6):970-7. doi: 10.2319/011905-17.
This study determined the effects of growth hormone (GH) therapy on craniofacial growth in idiopathic growth hormone deficiency (GHD).
Fifty-seven patients (33 boys and 24 girls; age range 4.5 to 16.7 years) with GHD were investigated and categorized into three groups according to the duration of GH therapy: the untreated group, the short-term therapy group, and the long-term therapy group. Their lateral cephalometric radiographs were studied, and craniofacial measurements were assessed by age and sex by using matched standard deviation scores.
In the untreated group, the anterior cranial base, total facial height, maxillary length, mandibular total length, mandibular body length, and ramus height were smaller than the standard values. In comparison with the untreated group, the long-term therapy group had a significantly larger upper facial height (P < .05), maxillary length (P < .01), and ramus height (P < .01) measurements.
Children who received long-term GH replacement therapy showed increased growth of the craniofacial skeleton, especially the maxilla and ramus. These findings suggest that GH accelerates craniofacial development, which improves occlusion and the facial profile.
本研究确定生长激素（GH）治疗对特发性生长激素缺乏症（GHD）患者颅面生长的影响。
对57例GHD患者（33例男孩和24例女孩；年龄范围4.5至16.7岁）进行调查，并根据GH治疗持续时间分为三组：未治疗组、短期治疗组和长期治疗组。研究他们的头颅侧位X线片，并使用匹配的标准差分数按年龄和性别评估颅面测量值。
在未治疗组中，前颅底、全脸高度、上颌长度、下颌总长度、下颌体长和下颌升支高度均小于标准值。与未治疗组相比，长期治疗组的上颌高度（P <.05）、上颌长度（P <.01）和下颌升支高度（P <.01）测量值明显更大。
接受长期GH替代治疗的儿童颅面骨骼生长增加，尤其是上颌骨和下颌升支。这些发现表明GH可加速颅面发育，从而改善咬合和面部轮廓。
