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[稳定A组链球菌L型与人心肌肌纤维的共同抗原]

[Common antigens of stable group A streptococcal L forms and muscle fibers of human myocardium].

作者信息

Beletskaia L V, Vul'fovich Iu V, Gnezditskaia E V, Goncharova S A, Ugriumova G A

出版信息

Biull Eksp Biol Med. 1978 Aug;86(8):207-9.

PMID:356911
Abstract

The immunofluorescence method was used to demonstrate that the antigens of stable streptococcus L-forms and of the cytoplasmic membrane of human myocardium muscle fibers were common. The common antigen was included into the composition of the surface membrane of the muscle cell adjacent to the sarcolemma, and of the transverse tubule membranes of the sarcoplasma reticulum passing in the Z-band region of the muscle fiber sarcomeres. The reactions is completely prevented by the exhaustion of the anti-serum to the antigen of the L-forms with the homogenate of human myocardium tissues or a suspension of the L-form cultures grown both on meat and on casein media. Exhaustion with tissue homogenate of other organs (the liver) or with concentrated nutrient medium practically failed to influence the extent of this reaction. The authors believe that the commonnes of the antigens of stable L-forms of streptococcus, group A, cultures and of the myocardium could serve as one of the causes of prolonged persistence of L-forms in human and animal organism.

摘要

采用免疫荧光法证明,A 组链球菌稳定 L 型菌的抗原与人心肌肌纤维细胞质膜的抗原相同。这种共同抗原存在于肌细胞临近肌膜的表面膜以及在肌纤维肌节 Z 带区域穿行的肌浆网横管膜的组成成分中。用人心肌组织匀浆或在肉培养基和酪蛋白培养基上培养的 L 型菌悬液耗尽抗 L 型菌抗原的抗血清后,该反应完全被阻止。用其他器官(肝脏)的组织匀浆或浓缩营养培养基耗尽抗血清,实际上对该反应的程度没有影响。作者认为,A 组链球菌稳定 L 型菌培养物与心肌抗原的相同性可能是 L 型菌在人和动物体内长期持续存在的原因之一。

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