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[稳定A组链球菌L型与人心肌肌纤维的共同抗原]

[Common antigens of stable group A streptococcal L forms and muscle fibers of human myocardium].

作者信息

Beletskaia L V, Vul'fovich Iu V, Gnezditskaia E V, Goncharova S A, Ugriumova G A

出版信息

Biull Eksp Biol Med. 1978 Aug;86(8):207-9.

PMID:356911
Abstract

The immunofluorescence method was used to demonstrate that the antigens of stable streptococcus L-forms and of the cytoplasmic membrane of human myocardium muscle fibers were common. The common antigen was included into the composition of the surface membrane of the muscle cell adjacent to the sarcolemma, and of the transverse tubule membranes of the sarcoplasma reticulum passing in the Z-band region of the muscle fiber sarcomeres. The reactions is completely prevented by the exhaustion of the anti-serum to the antigen of the L-forms with the homogenate of human myocardium tissues or a suspension of the L-form cultures grown both on meat and on casein media. Exhaustion with tissue homogenate of other organs (the liver) or with concentrated nutrient medium practically failed to influence the extent of this reaction. The authors believe that the commonnes of the antigens of stable L-forms of streptococcus, group A, cultures and of the myocardium could serve as one of the causes of prolonged persistence of L-forms in human and animal organism.

摘要

采用免疫荧光法证明,A 组链球菌稳定 L 型菌的抗原与人心肌肌纤维细胞质膜的抗原相同。这种共同抗原存在于肌细胞临近肌膜的表面膜以及在肌纤维肌节 Z 带区域穿行的肌浆网横管膜的组成成分中。用人心肌组织匀浆或在肉培养基和酪蛋白培养基上培养的 L 型菌悬液耗尽抗 L 型菌抗原的抗血清后,该反应完全被阻止。用其他器官(肝脏)的组织匀浆或浓缩营养培养基耗尽抗血清,实际上对该反应的程度没有影响。作者认为,A 组链球菌稳定 L 型菌培养物与心肌抗原的相同性可能是 L 型菌在人和动物体内长期持续存在的原因之一。

相似文献

1
[Common antigens of stable group A streptococcal L forms and muscle fibers of human myocardium].[稳定A组链球菌L型与人心肌肌纤维的共同抗原]
Biull Eksp Biol Med. 1978 Aug;86(8):207-9.
2
[Cross-reacting antigens of human thymus myoid cells and stable L-forms of group A streptococci].[人胸腺肌样细胞与A组链球菌稳定L型的交叉反应抗原]
Biull Eksp Biol Med. 1981 Jun;91(6):704-6.
3
[Reactions of antibodies to streptococcus group A antigens with fibroblasts of human heart interstitial connective tissue].[抗A组链球菌抗原的抗体与人心脏间质结缔组织成纤维细胞的反应]
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4
The experimental myocarditis of mice immunized with group A streptococcal cytoplasmic membrane fraction extracted from L-forms.用从L型提取的A组链球菌细胞质膜组分免疫小鼠的实验性心肌炎。
Jpn J Exp Med. 1982 Oct;52(5):267-70.
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[Detection of antigens of L-forms of hemolytic streptococcus in tissues of experimentally infected mice using the immunofluorescence reaction].[利用免疫荧光反应检测实验感染小鼠组织中溶血性链球菌L型抗原]
Biull Eksp Biol Med. 1972 Sep;73(9):65-7.
6
[Serologic indices of the persistence of L forms of group A streptococci in patients with rheumatism].
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7
[Myocardial anti-immunoglobulins and antibodies in sera against the ribosomes and surface antigenic determinants of microbial variants of Streptococcus group A].[心肌抗免疫球蛋白以及血清中针对A组链球菌微生物变体核糖体和表面抗原决定簇的抗体]
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8
L-forms of Pseudomonas aeruginosa. 3. The serological cross-reactions among stable L-forms of Pseudomonas aeruginosa, L-form of Streptococcus pyogenes and mycoplasmas.铜绿假单胞菌的L型。3. 铜绿假单胞菌稳定L型、化脓性链球菌L型与支原体之间的血清学交叉反应。
Jpn J Exp Med. 1978 Dec;48(6):545-51.
9
[Monoclonal antibodies cross-reacting with fibroblasts of interstitial connective tissue of the myocardium and cell wall protein antigens of group A Streptococcus].
Biull Eksp Biol Med. 1989 Jul;108(7):74-6.
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The common antigen(s) of streptococcal M protein vaccines causing hyperimmune reactions in man.在人类中引起超敏反应的链球菌M蛋白疫苗的共同抗原。
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