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由米淀粉纳米粒稳定的油包水 Pickering 乳液的流变性、稳定性、抗氧化性能和姜黄素释放。

Rheology, stability, antioxidant properties, and curcumin release of oil-in-water Pickering emulsions stabilized by rice starch nanoparticles.

机构信息

Department of Chemical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002, Thailand; Sustainable infrastructure Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand..

Department of Chemical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

Int J Biol Macromol. 2022 Aug 1;214:370-380. doi: 10.1016/j.ijbiomac.2022.06.032. Epub 2022 Jun 9.

Abstract

Modification of rice starch nanoparticles (SNP) as an emulsifier in Pickering emulsions is reported in this work. The SNP was prepared by HCl hydrolysis with different resident times and subsequently modified via crosslinking by citric acid using various crosslinking times to improve the hydrophobicity of SNP. The modified SNP was used to prepare sunflower oil-in-water Pickering emulsions loaded with curcumin. The optimal hydrolysis conditions (2.2 M HCl, 6 days) produced SNP with a 21.87 ± 0.69 % yield and 45.56 ± 0.00 % crystallinity. The citric acid-modified SNP with a 6-h crosslinking period (SNP-M-6 h) had a water contact angle of 87.2°. The suitable Pickering emulsion containing 30 wt% curcumin-loaded sunflower oil was stabilized by 3.0 wt% SNP-M-6 h. This Pickering emulsion had shear thinning properties with a pseudoplastic fluid behavior and was characterized by a droplet size of 47.16 ± 4.22 μm with a high degree of stability over five weeks of storage. Furthermore, the curcumin release from the emulsion depended on the pH, and curcumin could maintain its free radical scavenging quality. A very beneficial property of the Pickering emulsion is that it can slowly release curcumin at low pH, but more rapid release at higher pH, making it a potentially excellent candidate for drug delivery through oral intake.

摘要

本文报道了将大米淀粉纳米颗粒(SNP)改性为 Pickering 乳液中的乳化剂。SNP 通过不同停留时间的 HCl 水解制备,然后通过柠檬酸交联进行改性,以提高 SNP 的疏水性。使用改性后的 SNP 制备了负载姜黄素的葵花籽油/Water Pickering 乳液。最佳水解条件(2.2 M HCl,6 天)得到的 SNP 产率为 21.87±0.69%,结晶度为 45.56±0.00%。交联时间为 6 h 的柠檬酸改性 SNP(SNP-M-6 h)的水接触角为 87.2°。含有 30 wt%负载姜黄素的葵花籽油的合适 Pickering 乳液由 3.0 wt% SNP-M-6 h 稳定。该 Pickering 乳液具有剪切变稀特性,表现为假塑性流体行为,其特征为储存五周后,粒径为 47.16±4.22 μm,稳定性高。此外,乳液中姜黄素的释放取决于 pH 值,并且姜黄素可以保持其自由基清除质量。Pickering 乳液的一个非常有益的特性是,它可以在低 pH 值下缓慢释放姜黄素,但在较高 pH 值下释放更快,使其成为通过口服摄入进行药物传递的潜在优秀候选物。

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