高级别浆液性卵巢癌患者的严重副肿瘤性皮肌炎。
Severe Paraneoplastic Dermatomyositis in a Patient With High-Grade Serous Ovarian Cancer.
机构信息
Faculty of Medecine, University of Montréal, Montréal, QC.
Department of Obstetrics & Gynecology, University of Montréal, Montréal, QC.
出版信息
J Obstet Gynaecol Can. 2022 Jun;44(6):700-702. doi: 10.1016/j.jogc.2022.01.015.
BACKGROUND
Paraneoplastic dermatomyositis following a diagnosis of ovarian cancer is rare. There are very few cases reported on the management of severe forms.
CASE
We report the case of a 50-year-old woman diagnosed with stage IIIC high-grade serous ovarian cancer and a severe form of paraneoplastic dermatomyositis requiring mechanical ventilation. She had significant comorbidities further adding to the complexity of the chemotherapy regimen. Intravenous immunoglobulin and corticosteroids were also administered. The dermatomyositis remained poorly controlled, and the patient was ultimately referred to palliative care.
CONCLUSION
The necessity to treat the underlying neoplasia creates a fine balance between the aggressive treatments required and the clinical state of the patient. Multidisciplinary collaboration is warranted to offer best management.
背景
卵巢癌诊断后出现副肿瘤性皮肌炎较为罕见。关于严重形式的治疗，仅有少数病例报道。
病例
我们报告了一例 50 岁女性，诊断为 IIIC 期高级别浆液性卵巢癌和严重副肿瘤性皮肌炎，需要机械通气。她合并多种严重疾病，这进一步增加了化疗方案的复杂性。还给予了静脉注射免疫球蛋白和皮质类固醇治疗。皮肌炎仍未得到有效控制，患者最终被转至姑息治疗科。
结论
治疗潜在肿瘤的必要性在所需的积极治疗与患者的临床状况之间创造了微妙的平衡。需要多学科协作以提供最佳管理。
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