Department of Emergency Medicine, University of Alberta, Canada.
Department of Pediatrics (Division of Critical Care), University of Alberta, Canada.
Am J Emerg Med. 2022 Sep;59:215.e1-215.e5. doi: 10.1016/j.ajem.2022.05.051. Epub 2022 May 31.
Methemoglobinemia is the result of inappropriate oxidation of hemoglobin iron groups, leading to a failure of oxygen transport and delivery, resulting in a clinical state of refractory hypoxia. Methemoglobin levels above 70% are often considered fatal. Acquired methemoglobinemia can be caused by a variety of substances, including sodium nitrite, a commercially available food preservative and color fixative. This report describes a patient presenting with a methemoglobin level of 83% secondary to intentional sodium nitrite ingestion. The methemoglobin level recorded is amongst some of the highest found in surviving patients.
高铁血红蛋白血症是血红蛋白铁基团不当氧化的结果，导致氧运输和输送失败，从而导致难治性缺氧的临床状态。高铁血红蛋白水平高于 70%通常被认为是致命的。获得性高铁血红蛋白血症可由多种物质引起，包括亚硝酸钠，一种商业上可用的食品防腐剂和固色剂。本报告描述了一名因故意摄入亚硝酸钠而高铁血红蛋白水平为 83%的患者。所记录的高铁血红蛋白水平在存活患者中属于较高水平之一。
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