Toxicology Section, Centre of Forensic Sciences, Toronto, ON M3M 0B1, Canada.
J Anal Toxicol. 2023 Nov 1;47(8):750-752. doi: 10.1093/jat/bkad067.
An increase in suicide cases by sodium nitrate and sodium nitrite ingestion has been noted in the scientific literature. We report on the possible impact of nitrate/nitrite-caused methemoglobinemia on carboxyhemoglobin measurement by spectrophotometric methods. Elevated methemoglobin saturation may result in insufficient reducing agents to convert methemoglobin into deoxygenated hemoglobin, affecting the measured total hemoglobin and carboxyhemoglobin saturation. We highlight four cases where the cause of death was attributed to sodium nitrate or sodium nitrite ingestion. The possible impact of the nitrate/nitrite-caused methemoglobinemia on the carboxyhemoglobin saturation as measured by spectrophotometry is discussed. Further studies are needed to identify a causal relationship between nitrate/nitrite-caused methemoglobinemia and carboxyhemoglobin saturation as measured by spectrophotometric methods.
科学文献中注意到，由于摄入硝酸钠和亚硝酸钠，自杀案例有所增加。我们报告了硝酸盐/亚硝酸盐引起的高铁血红蛋白血症对分光光度法测量碳氧血红蛋白可能产生的影响。高铁血红蛋白饱和度的升高可能导致还原试剂不足，无法将高铁血红蛋白转化为去氧血红蛋白，从而影响总血红蛋白和碳氧血红蛋白饱和度的测量值。我们强调了四起死因归因于摄入硝酸钠或亚硝酸钠的案例。讨论了分光光度法测量的高铁血红蛋白血症对碳氧血红蛋白饱和度的可能影响。需要进一步的研究来确定分光光度法测量的硝酸盐/亚硝酸盐引起的高铁血红蛋白血症与碳氧血红蛋白饱和度之间的因果关系。
