Liu J J, Wang L L, Huang Y F
The Ophthalmology Division of Chinese PLA General Hospital, Beijing 100853, China.
Zhonghua Yan Ke Za Zhi. 2022 Jun 11;58(6):461-466. doi: 10.3760/cma.j.cn112142-20210629-00300.
Keratopathy is one of the most important blinding eye diseases in the world. Corneal opacity caused by keratopathy can seriously damage visual function. For example, corneal ulcer can lead to perforation and even loss of the eyeball. Although corneal transplantation is a routine treatment in clinical practice, there are not only a serious shortage of corneal donors in our country, but also various complications after keratoplasty that can not be avoided. In recent years, with the rapid development of regenerative medicine, it has been found that mesenchymal stem cells can differentiate into a variety of functional cells including corneal tissue under suitable induction conditions, which has a broad prospect of clinical application. This finding provides new ideas and methods for the treatment of keratopathy and corneal blindness in many aspects. This article reviews the research status of induction methods of mesenchymal stem cells in various specialties, particularly in the corneal subspecialty.
角膜病是世界上最重要的致盲眼病之一。角膜病引起的角膜混浊可严重损害视功能。例如，角膜溃疡可导致穿孔甚至眼球丧失。虽然角膜移植是临床常规治疗方法，但我国不仅角膜供体严重短缺，而且角膜移植术后还存在各种难以避免的并发症。近年来，随着再生医学的快速发展，发现间充质干细胞在合适的诱导条件下可分化为包括角膜组织在内的多种功能细胞，具有广阔的临床应用前景。这一发现为角膜病和角膜盲的治疗在诸多方面提供了新的思路和方法。本文综述了间充质干细胞在各个专业尤其是角膜亚专业中的诱导方法的研究现状。
