Baggot J D, Prescott J F
Equine Vet J. 1987 Mar;19(2):92-6. doi: 10.1111/j.2042-3306.1987.tb02596.x.
The success of antimicrobial therapy depends on administration of an agent to which the pathogenic microorganisms are susceptible at the concentrations attained at the site of infection. The route of administration, size of the dose and dosing interval must be appropriate for the drug preparation selected. With penicillins in particular, dosage can be tailored to the severity of the infection and quantitative susceptibility of the microorganism. This approach cannot be applied to aminoglycosides because their relatively narrow margin of safety limits the amount which can be administered. In severe infections it is important quickly to establish effective antimicrobial concentrations, which means that the choice of drug must be based on experience in treating the particular type of infection (empiric selection) and its dosage be adequate to produce a high peak concentration in the plasma. In treating septicaemic conditions of neonatal foals the deficit in serum immunoglobulins should be corrected, and it is advisable to administer antimicrobial agents or combinations that produce a bactericidal effect at dosages modified for immature physiological processes.
抗菌治疗的成功取决于给予一种病原体微生物在感染部位所能达到的浓度下敏感的药物。给药途径、剂量大小和给药间隔必须适合所选的药物制剂。特别是对于青霉素，剂量可以根据感染的严重程度和微生物的定量敏感性进行调整。这种方法不适用于氨基糖苷类药物，因为它们相对较窄的安全范围限制了可给药的量。在严重感染中，迅速建立有效的抗菌浓度很重要，这意味着药物的选择必须基于治疗特定类型感染的经验（经验性选择），并且其剂量要足以在血浆中产生高的峰值浓度。在治疗新生驹的败血症时，应纠正血清免疫球蛋白的不足，并且建议给予在针对未成熟生理过程调整剂量时能产生杀菌作用的抗菌药物或联合用药。
