Belyaev Andrei M, Lewis Clinton, Doocey Richard, Bergin Colleen J
Green Lane Cardiothoracic Surgical Unit, Auckland City Hospital, Auckland, New Zealand.
Bone Marrow Transplant Unit, Haematology Department, Auckland City Hospital, Auckland, New Zealand.
Asia Pac J Clin Oncol. 2023 Apr;19(2):e89-e95. doi: 10.1111/ajco.13797. Epub 2022 Jun 12.
Socioeconomic deprivation (SED) is a risk factor for reduced survival of hematopoietic stem cell transplant (HSCT) recipients. This study aimed to evaluate access and long-term survival of HSCT recipients.
This was a hospital HSCT Registry-based retrospective cohort study. Patients who underwent HSCT from January 2010 to June 2020 were identified. HSCT recipients younger than 16 years of age, patients who reported their residential address as a post office box or the Department of Corrections, and those who left the country after HSCT were excluded from the study. HSCT recipients with the 2018 New Zealand deprivation index (NZDep2018) deciles 8, 9, and 10 were assigned to the higher SED group and those with NZDep2018 deciles from 1 to 7 were allocated to the lower SED group. The total number of New Zealanders in the higher and lower SED strata was obtained from the 2018 Census.
Eight hundred fifty-one HSCT recipients met the eligibility criteria. HSCT recipients from the higher and lower SED strata of the New Zealand population had similar access to HSCT (odds ratio = .9; 95% confidence interval (CI): .77-1.04; p = .155). Mortality in the higher and lower SED groups of HSCT recipients was 9.6/100 person-years (95% CI: 7.7-12/100 person-years) and 8.1/100 person-years (95% CI: 6.9-9.4/100 person-years), respectively. The mortality ratio was 1.2 (95% CI: .9-1.6), p = .098. Both groups had similar survival.
New Zealand residents from the higher and lower SED strata have similar access to HSCT. SED is not associated with reduced survival in adult HSCT recipients.
社会经济剥夺（SED）是造血干细胞移植（HSCT）受者生存降低的一个风险因素。本研究旨在评估HSCT受者的可及性和长期生存情况。
这是一项基于医院HSCT登记处的回顾性队列研究。确定了2010年1月至2020年6月期间接受HSCT的患者。16岁以下的HSCT受者、将其居住地址报告为邮政信箱或惩教部的患者，以及HSCT后离开该国的患者被排除在研究之外。2018年新西兰剥夺指数（NZDep2018）十分位数为8、9和10的HSCT受者被分配到较高SED组，而NZDep2018十分位数为1至7的受者被分配到较低SED组。较高和较低SED阶层的新西兰人的总数来自2018年人口普查。
851名HSCT受者符合纳入标准。新西兰人群中较高和较低SED阶层的HSCT受者接受HSCT的机会相似（优势比=0.9；95%置信区间（CI）：0.77 - 1.04；p = 0.155）。HSCT受者较高和较低SED组的死亡率分别为9.6/100人年（95%CI：7.7 - 12/100人年）和8.1/100人年（95%CI：6.9 - 9.4/100人年）。死亡率比值为1.2（95%CI：0.9 - 1.6），p = 0.098。两组的生存率相似。
较高和较低SED阶层的新西兰居民接受HSCT的机会相似。SED与成年HSCT受者的生存降低无关。
