[俄罗斯心力衰竭患者的缺铁情况。观察性横断面多中心研究]

[Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study].

作者信息

Mareev V Yu, Begrambekova Yu L, Mareev Yu V, Kobalava Zh D, Karapetyan L V, Galochkin S A, Kazakhmedov E R, Lapshin A A, Garganeeva A A, Kuzheleva E A, Efremushkina A А, Kiseleva E V, Barbarash O L, Pecherina T B, Galyavich A S, Galeeva Z M, Baleeva L V, Koziolova N A, Veklich A S, Duplyakov D V, Maksimova M N, Yakushin S S, Smirnova E A, Sedykh E V, Shaposhnik I I, Makarova N A, Zemlyanukhina A A, Skibitsky V V, Fendrikova A V, Skibitsky A V, Spiropulos N A, Seredenina E M, Orlova Ya A, Eruslanova K A, Kotovskaya Yu V, Tkacheva O N, Fedin M A

机构信息

Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University.

National Medical Research Center for Therapy and Preventive Medicine; Medical Research and Educational Center, Lomonosov Moscow State University.

出版信息

Kardiologiia. 2022 May 31;62(5):4-8. doi: 10.18087/cardio.2022.5.n2083.

DOI:10.18087/cardio.2022.5.n2083

PMID:35692168

Abstract

Aim To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).Material and methods Iron metabolism variables were studied in 498 (198 women, 300 men) patients with HF. Data were evaluated at admission for HF (97 %) or during an outpatient visit (3 %). ID was determined according to the European Society of Cardiology Guidelines.Results 83.1 % of patients had ID; only 43.5 % of patients with ID had anemia. Patients with ID were older: 70.0 [63.0;79.0] vs. 66.0 years [57.0;75.2] (p=0.009). The number of patients with ID increased in parallel with the increase in HF functional class (FC). Among patients with ID, fewer people were past or current alcohol users (p=0.002), and a greater number of patients had atrial fibrillation (60.1 vs. 45.2 %, p=0.016). A multiple logistic regression showed that more severe HF (HF FC) was associated with a higher incidence of ID detection, whereas past alcohol use was associated with less pronounced ID. An increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) by 100 pg/ml was associated with an increased likelihood of ID (odds ratio, 1.006, 95 % confidence interval: 1.002-1.011, p=0.0152).Conclusion The incidence rate of HF patients is high in the Russian Federation (83.1 %). Only 43.5 % of these patients had anemia. The prevalence of ID in the study population increased with increases in HF FC and NT-proBNP.

摘要

目的评估俄罗斯心力衰竭（HF）患者中铁缺乏（ID）的患病率。

材料与方法对498例（198例女性，300例男性）HF患者的铁代谢变量进行了研究。数据在HF入院时（97%）或门诊就诊期间（3%）进行评估。根据欧洲心脏病学会指南确定ID。

结果 83.1%的患者存在ID；ID患者中仅有43.5%患有贫血。ID患者年龄更大：70.0[63.0；79.0]岁 vs. 66.0岁[57.0；75.2]（p=0.009）。ID患者数量随HF功能分级（FC）增加而平行增加。在ID患者中，既往或当前饮酒者较少（p=0.002），且心房颤动患者更多（60.1%对45.2%，p=0.016）。多因素逻辑回归显示，更严重的HF（HF FC）与ID检出率较高相关，而既往饮酒与ID不那么明显相关。N末端脑钠肽前体（NT-proBNP）每增加100 pg/ml与ID可能性增加相关（比值比，1.006，95%置信区间：1.002-1.011，p=0.0152）。

结论俄罗斯联邦HF患者的发病率较高（83.1%）。这些患者中仅有43.5%患有贫血。研究人群中ID的患病率随HF FC和NT-proBNP的增加而增加。