Department of Emergency Medicine, Cangzhou Central Hospital, Cangzhou, China.
People's Hospital of Qingxian, Qingxian, China.
Dis Markers. 2022 Jun 3;2022:6053410. doi: 10.1155/2022/6053410. eCollection 2022.
To explore the effect of calcitriol combined with zoledronic acid in posterior cruciate ligament tibial avulsion fractures of the knee joint in patients with diabetic osteoporosis.
Between January 2020 and January 2022, 60 patients with diabetic osteoporosis treated in our hospital were included. All patients underwent knee joint posterior cruciate ligament tibial avulsion fractures, and they were randomized (1 : 1) into the observation group (calcitriol combined with zoledronic acid) and control group (calcitriol). The two groups were compared with respect to the improvement of bone mineral density and bone metabolism indexes, the pain degree (VAS) and knee joint function (Lysholm), and the incidence of refracture.
Both groups showed an increasing bone mineral density after treatment, and significant increase was observed in the observation group vs. control group (all < 0.05). After treatment, VAS scores decreased in the two groups, and Lysholm scores increased compared to the corresponding values before treatment (all < 0.05), with more notable changes in the observation group versus control group (all < 0.05). The observation group had fewer cases of refractures than the control group (2 cases vs. 8 cases) ( < 0.05).
Calcitriol combined with zoledronic acid used in patients with diabetic osteoporosis after the posterior cruciate ligament tibial attachment avulsion fracture of the knee joint yields a promising result in enhancing bone mineral density and bone metabolism indicators, relieving pain, improving knee joint function, and reducing the risk of refracture.
探讨骨化三醇联合唑来膦酸治疗糖尿病骨质疏松性膝关节后交叉韧带胫骨止点撕脱骨折的效果。
选取 2020 年 1 月至 2022 年 1 月我院收治的 60 例糖尿病骨质疏松性膝关节后交叉韧带胫骨止点撕脱骨折患者，所有患者均接受膝关节后交叉韧带胫骨止点撕脱骨折手术治疗，采用随机数字表法将其分为观察组（骨化三醇联合唑来膦酸）和对照组（骨化三醇），各 30 例。比较两组患者的骨密度及骨代谢指标改善情况、疼痛程度（VAS）、膝关节功能（Lysholm）评分以及再骨折发生率。
两组患者治疗后骨密度均升高，观察组高于对照组（均 < 0.05）。两组患者治疗后 VAS 评分均降低，Lysholm 评分均高于治疗前（均 < 0.05），观察组变化幅度大于对照组（均 < 0.05）。观察组再骨折发生率低于对照组（2 例比 8 例）（ < 0.05）。
骨化三醇联合唑来膦酸治疗糖尿病骨质疏松性膝关节后交叉韧带胫骨止点撕脱骨折，可提高骨密度和骨代谢指标，缓解疼痛，改善膝关节功能，降低再骨折风险。
