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中枢神经系统出血性病变:一名人类免疫缺陷病毒感染及获得性免疫缺陷综合征患者的弓形虫病

Hemorrhagic Lesions in the Central Nervous System: Toxoplasmosis in a Person Living With Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome.

作者信息

Arora Navneet, Kotwani Sejal, Chhabra Manika, H Mohan

机构信息

Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IND.

Radiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IND.

出版信息

Cureus. 2022 May 8;14(5):e24827. doi: 10.7759/cureus.24827. eCollection 2022 May.

Abstract

Central nervous system (CNS) toxoplasmosis is one of the common causes of hemorrhagic brain lesions in people living with HIV and AIDS (PLWHA), resulting in high mortality and morbidity. It has a broad clinical and neuro-radiological spectrum, which may or may not be limited to typical findings of focal and subacute neurological deficits or ring-enhancing lesions in the basal ganglia. Here, we present a case of a patient who is a newly detected person living with HIV and AIDS with a low CD cell count and classical imaging findings of central nervous system toxoplasmosis on his magnetic resonance imaging (MRI) of the brain. The incidence of opportunistic infections has been reduced after introducing highly active antiretroviral therapy (HAART); this case will be helpful to clinicians in identifying CNS toxoplasmosis as it has classical imaging findings on the MRI brain.

摘要

中枢神经系统(CNS)弓形虫病是人类免疫缺陷病毒(HIV)感染者和艾滋病患者(PLWHA)出现出血性脑病变的常见原因之一,可导致高死亡率和高发病率。它具有广泛的临床和神经放射学表现,可能局限于典型的局灶性和亚急性神经功能缺损或基底节区环形强化病变,也可能并非如此。在此,我们报告一例新确诊的HIV感染者和艾滋病患者,其CD细胞计数低,脑部磁共振成像(MRI)有中枢神经系统弓形虫病的典型影像学表现。引入高效抗逆转录病毒疗法(HAART)后,机会性感染的发生率有所降低;该病例有助于临床医生识别中枢神经系统弓形虫病,因为其脑部MRI有典型的影像学表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/9173227/b4eae4e5d8fb/cureus-0014-00000024827-i01.jpg

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