Bahar R H, Abdel Dayem H M, Mohammed M, Simo M, Ziada G, Costantinides C, Suhali A R
Eur J Nucl Med. 1987;12(11):542-5. doi: 10.1007/BF00296093.
Pulmonary hypertension (PH) produces strain followed by hypertrophy and later dilatation of the right ventricle (RV) and pulmonary artery. The signs and symptoms are nonspecific. There is a need for a noninvasive sensitive way to diagnose PH. The purpose of this study is to evaluate phase abnormalities in radionuclide MUGA studies of patients with referred diagnosis of PH. In a retrospective analysis of 44 patients who had a radionuclide multigated study (MUGA) and contrast ventriculography (CV), 19 had high mean pulmonary pressure (over 20 mmHg) and a high pulmonary vascular resistance index (over 2.0). In 15 patients, a delayed phase segment in the RV corresponding to the pulmonary infundibulum and pulmonary conus was noted "The Pulmonary Tongue" sign (PT), 12 had PH (True positive) and 3 did not (false positive) on CV. No PT was seen in the remaining 29 patients, only 7 of them had PH (False negative). The sensitivity, specificity and accuracy of the PT sign in detecting PH was 80%, 72% and 77% respectively. The number of patients was too small to calculate the correlation of the grade of PT with the severity of PH. We conclude that "The Pulmonary Tongue" sign on a MUGA study is clinically useful in detecting PH.
肺动脉高压（PH）会导致右心室（RV）和肺动脉出现应变，随后发生肥厚，最终出现扩张。其体征和症状并无特异性。因此需要一种非侵入性的敏感方法来诊断PH。本研究的目的是评估被转诊诊断为PH的患者在放射性核素门控心血池显像（MUGA）研究中的相位异常情况。在一项对44例接受放射性核素多门控研究（MUGA）和对比心室造影（CV）的患者的回顾性分析中，19例患者平均肺动脉压较高（超过20 mmHg）且肺血管阻力指数较高（超过2.0）。在15例患者中，观察到右心室对应于肺动脉漏斗部和肺动脉圆锥的延迟相节段出现 “肺舌” 征（PT），其中12例在CV检查中患有PH（真阳性），3例未患有PH（假阳性）。其余29例患者未观察到PT征，其中只有7例患有PH（假阴性）。PT征检测PH的敏感性、特异性和准确性分别为80%、72%和77%。患者数量过少，无法计算PT分级与PH严重程度之间的相关性。我们得出结论，MUGA研究中的 “肺舌” 征在临床上对检测PH很有用。
