Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction of Ministry of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China.
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Front Immunol. 2022 May 26;13:907287. doi: 10.3389/fimmu.2022.907287. eCollection 2022.
Avian leukosis virus (ALV) causes various diseases associated with tumor formation and decreased fertility. Moreover, ALV induces severe immunosuppression, increasing susceptibility to other microbial infections and the risk of failure in subsequent vaccination against other diseases. There is growing evidence showing the interaction between ALV and the host. In this review, we will survey the present knowledge of the involvement of host factors in the important molecular events during ALV infection and discuss the futuristic perspectives from this angle.
禽白血病病毒(ALV)可引起多种与肿瘤形成和生育力下降相关的疾病。此外,ALV 可诱导严重的免疫抑制,增加对其他微生物感染的易感性,并增加随后对其他疾病疫苗接种失败的风险。越来越多的证据表明 ALV 与宿主之间存在相互作用。在这篇综述中,我们将调查宿主因素参与 ALV 感染过程中重要分子事件的现有知识,并从这一角度探讨未来的前景。