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因摄入含左旋咪唑的可卡因导致的双重自杀:病例报告及文献综述

Double Suicide Due to the Ingestion of Levamisole-Adulterated Cocaine: Case Report and Review of the Literature.

作者信息

Serinelli Serenella, Bonaccorso Luigi, Furnari Carmelo, Gitto Lorenzo

出版信息

Acad Forensic Pathol. 2022 Mar;12(1):23-30. doi: 10.1177/19253621211065334. Epub 2021 Dec 13.

Abstract

Suicide is a major public health issue and the risk of attempting and committing suicide increases with age. We present the case of an elderly couple who decided to commit suicide together by self-poisoning using levamisole-adulterated cocaine. The choice of committing a double suicide, the method selected (self-poisoning), the drug self-administered (cocaine), and the route of administration (ingestion) are events rarely encountered in the forensic pathology practice, especially not in combination. In this article, we will review the literature regarding the frequency and features of these methods of suicide. An overview of the effects and mechanism of action of levamisole is also provided, highlighting the importance of including this substance and its metabolites in the routine toxicological analyses for cocaine deaths.

摘要

自杀是一个重大的公共卫生问题,自杀未遂和自杀的风险会随着年龄的增长而增加。我们报告了一对老年夫妇的案例,他们决定一起通过服用掺有左旋咪唑的可卡因进行自我中毒自杀。选择双双自杀、所选的方法(自我中毒)、自行服用的药物(可卡因)以及给药途径(摄入),这些情况在法医病理学实践中很少遇到,尤其是不会同时出现。在本文中,我们将回顾关于这些自杀方法的频率和特征的文献。还提供了左旋咪唑的作用效果及作用机制概述,强调了在可卡因死亡的常规毒理学分析中纳入这种物质及其代谢物的重要性。

相似文献

6
Levamisole in Illicit Trafficking Cocaine Seized: A One-Year Study.非法交易可卡因中发现左旋咪唑:为期一年的研究。
J Psychoactive Drugs. 2017 Nov-Dec;49(5):408-412. doi: 10.1080/02791072.2017.1361558. Epub 2017 Aug 16.
7
Aminorex poisoning in cocaine abusers.可卡因滥用者中的氨苯恶唑中毒。
Int J Cardiol. 2012 Jul 26;158(3):344-6. doi: 10.1016/j.ijcard.2011.06.105. Epub 2011 Jul 20.

本文引用的文献

1
Cocaine Use and Levamisole-Induced Vasculitis: A Multiple Case Study.可卡因使用与左旋咪唑诱导性血管炎:多案例研究。
J Wound Ostomy Continence Nurs. 2020 Mar/Apr;47(2):182-189. doi: 10.1097/WON.0000000000000628.
2
Levamisole: A High Performance Cutting Agent.左旋咪唑:一种高效切割剂。
Acad Forensic Pathol. 2017 Sep;7(3):469-476. doi: 10.23907/2017.039. Epub 2017 Sep 1.
3
Nitrogen inhalation suicide pacts.吸入氮气自杀协议。
Med Sci Law. 2019 Jan;59(1):57-60. doi: 10.1177/0025802419828914. Epub 2019 Feb 13.
8
Suicide in older adults: current perspectives.老年人自杀:当前的观点。
Clin Interv Aging. 2018 Apr 20;13:691-699. doi: 10.2147/CIA.S130670. eCollection 2018.
9
Levamisole in Illicit Trafficking Cocaine Seized: A One-Year Study.非法交易可卡因中发现左旋咪唑:为期一年的研究。
J Psychoactive Drugs. 2017 Nov-Dec;49(5):408-412. doi: 10.1080/02791072.2017.1361558. Epub 2017 Aug 16.

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