Azad Chandrika, Guglani Vishal, Siddiqui Anam, Singh Sukhvinder
Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.
Department of General Medicine, Dr. Harvansh Singh Judge Institute of Dental Sciences, Punjab University, Chandigarh, India.
J Neurosci Rural Pract. 2022 Mar 2;13(2):301-306. doi: 10.1055/s-0042-1743459. eCollection 2022 Apr.
Children with epilepsy (CWE) are at high risk of psychopathological problems because of neurobiological, social, and treatment factors. This study was conducted to estimate the prevalence of psychopathological problems in CWE and their contributing factors. This cross-sectional study was done in pediatric neurology clinic and outpatient department of a government medical college in Northern India. Children between the ages of 4 and 14 years with intelligence quotient > 70 were enrolled; for CWE, the criteria were antiepileptic drugs therapy for more than 6 months and for controls it was being free from any chronic illness. Childhood Psychopathology Measurement Schedule (CPMS) was used for assessing psychopathological problems. A total of 135 CWE and 70 controls were enrolled, groups were similar in respect of age, gender, socioeconomic status, and family history. CWE group had significantly high mean standard deviation CPMS scores (13.68 10.57) as compared with controls (9.75 7.97) ( < 0.0001). These scores were particularly high in sectors of low intelligence, conduct disorder, psychotic symptoms, and depression. Academic performance was significantly poor in CWE (39%) versus controls (6%) ( 0.042). Age of onset, duration, type, and etiology of epilepsy had no significant relation with CPMS scores. Polytherapy and treatment with valproate were associated with high CPMS scores ( 0.005 and 0.045). Psychopathological problems are frequently associated with epilepsy in children and antiepileptic drug therapy might contribute to it.
由于神经生物学、社会和治疗因素，癫痫患儿（CWE）出现精神病理问题的风险很高。本研究旨在评估CWE中精神病理问题的患病率及其影响因素。这项横断面研究在印度北部一所政府医学院的儿科神经科诊所和门诊部进行。纳入了年龄在4至14岁、智商>70的儿童；对于CWE，标准是接受抗癫痫药物治疗超过6个月，而对照组则是没有任何慢性病。使用儿童精神病理学测量量表（CPMS）评估精神病理问题。共纳入了135名CWE和70名对照组，两组在年龄、性别、社会经济地位和家族史方面相似。与对照组（9.75±7.97）相比，CWE组的CPMS平均得分（13.68±10.57）显著更高（P<0.0001）。在智力低下、品行障碍、精神病症状和抑郁方面，这些得分尤其高。CWE的学业成绩（39%）明显低于对照组（6%）（P=0.042）。癫痫的发病年龄、病程、类型和病因与CPMS得分无显著关系。联合治疗和使用丙戊酸盐治疗与较高的CPMS得分相关（P=0.005和0.045）。儿童癫痫常伴有精神病理问题，抗癫痫药物治疗可能是其原因之一。
