热性惊厥患儿与发热对照儿童血清白细胞介素-6水平的比较分析
A Comparative Analysis of Serum Interleukin-6 Levels in Children with Febrile Seizures and Febrile Controls.
作者信息
Kumar K Jagadish, Kurvari Gaurav, Kumar H C Krishna, Tejashree A, Manjunath V G
机构信息
Jagadguru Sri Shivarathreeshwara Medical College, Jagadguru Sri Shivarathreeshwara Academy of Higher Education and Research, Mysuru, Karnataka, India.
出版信息
J Neurosci Rural Pract. 2022 Mar 28;13(2):336-338. doi: 10.1055/s-0042-1744226. eCollection 2022 Apr.
Febrile seizures (FSs) are the common presentations of seizures in childhood. Activation of cytokine network plays a significant role in the genesis of FSs. Interleukin (IL)-6 is often considered as key cytokine in the generation of FSs. To compare the serum IL-6 levels in children between simple febrile seizures (SFSs) and febrile controls (FCs). This hospital-based prospective cross-sectional study was conducted in JSS Hospital, Mysuru, during a period of 21 months. A total of 83 children were included in the study. Out of which, 38 were cases of SFSs and 45 were FCs without seizures. Serum IL-6 levels were estimated in both SFS and FC groups. Serum IL-6 levels were increased among children with SFSs (mean = 608.15 pg/mL) when compared with FCs (mean = 342 pg/mL), but the results are not statistically significant ( = 0.165). In SFS and FC groups, percentage of subjects with IL-6 levels >50 pg/mL is 31.6 and 44.4%, respectively ( = 0.16). Serum IL-6 levels are higher in children with SFSs compared with FCs. However, this difference did not reach statistical significance.
热性惊厥（FSs）是儿童期惊厥的常见表现形式。细胞因子网络的激活在热性惊厥的发生中起重要作用。白细胞介素（IL）-6常被认为是热性惊厥发生中的关键细胞因子。
为比较单纯热性惊厥（SFSs）患儿与热性对照（FCs）患儿的血清IL-6水平。
这项基于医院的前瞻性横断面研究在迈索尔的JSS医院进行，为期21个月。共有83名儿童纳入研究。其中，38例为SFSs患儿，45例为无惊厥的FCs患儿。对SFS组和FC组均进行血清IL-6水平测定。
与FCs患儿（均值 = 342 pg/mL）相比，SFSs患儿的血清IL-6水平升高（均值 = 608.15 pg/mL），但结果无统计学意义（P = 0.165）。在SFS组和FC组中，IL-6水平>50 pg/mL的受试者百分比分别为31.6%和44.4%（P = 0.16）。
与FCs患儿相比，SFSs患儿的血清IL-6水平更高。然而，这种差异未达到统计学意义。
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