萎缩对肌肉再支配效率的影响。

Influence of atrophy on the efficiency of muscle reinnervation.

作者信息

Brunetti O, Carobi C, Pazzaglia U

出版信息

Exp Neurol. 1987 May;96(2):248-52. doi: 10.1016/0014-4886(87)90043-4.

Abstract

The effectiveness of motor reinnervation carried out after an interval of 20 days between nerve transection and reimplantation onto a foreign muscle was studied in the rat. Sixty days after reimplantation the compound action potential, the maximal indirect twitch and tetanic tensions, and weight loss were evaluated. The functional data demonstrated an incomplete recovery which differed from the complete functional restoration observed in an acutely denervated muscle reinnervated with a chronically severed nerve. Time-dependent changes induced in the muscle by denervation seem therefore to influence the efficacy of motor reinnervation.

摘要

在大鼠身上研究了在神经切断与重新植入异体肌肉间隔20天后进行运动再支配的有效性。重新植入60天后，评估复合动作电位、最大间接单收缩和强直张力以及体重减轻情况。功能数据显示恢复不完全，这与用慢性切断的神经重新支配急性失神经肌肉时观察到的完全功能恢复不同。因此，失神经在肌肉中引起的时间依赖性变化似乎会影响运动再支配的效果。