Department of Hematology, Confluent Private Hospital, Nantes, France.
Nuclear Medecine, Institut Inter-RégionaL de Cancérologie Jean Bernard, Victor Hugo Medical Center, Le Mans, France.
CNS Oncol. 2022 Sep 1;11(3):CNS88. doi: 10.2217/cns-2021-0011. Epub 2022 Jun 13.
Primary CNS involvement is very rare in Hodgkin lymphoma. Here we present two cases of spinal cord dissemination. Two women of 40 and 65 years of age presented symptoms of spinal cord injury; imaging showed an intramedullary mass in T10 and T2, respectively, without vertebral involvement and upper diaphragmatic lymph nodes. Lymph-node biopsy confirmed the diagnosis of classical Hodgkin lymphoma in both patients. The first patient received four cycles of chemotherapy (escalated BEACOPP and ABVD) with intrathecal therapy, and the second four cycles of doxorubicin, vinblastine, dacarbazine (AVD) and local irradiation after surgery decompression. Complete metabolic response was obtained at the end of treatment. After 5 and 7 years of follow-up respectively, neurological deficits persisted in both.
原发性中枢神经系统受累在霍奇金淋巴瘤中非常罕见。我们在此介绍两例脊髓播散病例。两名分别为 40 岁和 65 岁的女性出现脊髓损伤症状；影像学显示 T10 和 T2 分别存在髓内肿块，无椎体受累和上膈淋巴结。淋巴结活检均证实为两例经典霍奇金淋巴瘤。第一例患者接受了四个周期的化疗（递增 BEACOPP 和 ABVD 方案）联合鞘内治疗，第二例患者在手术后接受了四个周期的多柔比星、长春碱、达卡巴嗪（AVD）和局部放疗。治疗结束时获得完全代谢缓解。分别随访 5 年和 7 年后，两名患者的神经功能缺损仍持续存在。
