Centre for Discover Brain Sciences, Deanery of Biomedical Sciences, University of Edinburgh, UK.
Department of Bioengineering and Centre for Neurotechnology, Imperial College London, London, UK.
Cogn Neurosci. 2022 Jul;13(3-4):141-143. doi: 10.1080/17588928.2022.2076076. Epub 2022 Jun 13.
The role of the hippocampus during memory consolidation is not fully understood, with human and animal experiments producing conflicting conclusions. In particular, human lesion studies tend to indicate that the hippocampus gradually becomes independent from memory over years, whilst animal studies suggest that this can happen over days. Tallman et al. (this issue) used fMRI to investigate activity and functional connectivity in the brain at four different time points following memory encoding. Their findings include a decrease in functional connectivity between the hippocampus and parahippocampal cortex with memory age, which supports the system consolidation theory, but also argues against the reduced involvement of the hippocampus over time. This study sheds new light on the neurobiology of memory.
海马体在记忆巩固过程中的作用尚未完全阐明，人类和动物实验得出了相互矛盾的结论。特别是，人类的病变研究往往表明，随着时间的推移，海马体逐渐脱离记忆，而动物研究则表明，这种情况可能在几天内发生。Tallman 等人（本期）使用 fMRI 在记忆编码后四个不同时间点研究大脑的活动和功能连接。他们的研究结果包括海马体与旁海马皮质之间的功能连接随着记忆年龄的增长而降低，这支持了系统巩固理论，但也反对随着时间的推移海马体参与度降低的观点。这项研究为记忆的神经生物学提供了新的视角。
