Department of Molecular Sciences, Swedish University of Agricultural Sciences, Box 7015, 75007 Uppsala, Sweden.
Dalton Trans. 2022 Jun 21;51(24):9511-9521. doi: 10.1039/d2dt00717g.
In the pursuit of understanding the factors guiding interactions between polyoxometalates (POMs) and biomolecules, several complexes between Keggin phosphomolybdate and diglycine have been produced at different acidity and salinity conditions, leading to difference in stoichiometry and in crystal structure. Principal factors determining how the POM and dipeptide interact appear to be pH, ionic strength of the medium, and the molar ratio of POM to peptide. An important effect turned out to be even the structure-directing role of the sodium cations coordinating carbonyl functions of the peptide bond. Given the interest in applying POMs in biological systems, these factors are highly relevant to consider. In the view of recent interest in using POMs as nano catalysts in peptide hydrolysis also the potential Keggin POM transformation in phosphate buffered saline medium was investigated leading to insight that nanoparticles of zirconium phosphate (ZrP) can be actual catalysts for breakdown of the peptide bond.
在探索多金属氧酸盐（POMs）与生物分子相互作用的因素过程中，我们在不同的酸度和盐度条件下合成了 Keggin 磷酸钼和二肽的几种复合物，导致其化学计量和晶体结构有所不同。决定 POM 和二肽如何相互作用的主要因素似乎是 pH 值、介质的离子强度以及 POM 与肽的摩尔比。一个重要的影响因素甚至是配位肽键羰基功能的钠离子的结构导向作用。鉴于人们对将 POMs 应用于生物系统的兴趣，这些因素是需要高度关注的。鉴于人们对将 POMs 作为纳米催化剂用于肽水解的兴趣，我们还研究了 Keggin POM 在磷酸盐缓冲盐介质中的潜在转化，从而深入了解到磷酸锆（ZrP）纳米粒子可以实际作为肽键断裂的催化剂。
