D'Angio G J
Cancer. 1978 Aug;42(2 Suppl):1015-25. doi: 10.1002/1097-0142(197808)42:2+<1015::aid-cncr2820420725>3.0.co;2-g.
Potential posttreatment complications for patients with the lymphomas and leukemia include: 1) impairment of growth and development in children, 2) CNS disturbances encompassing psychologic, intellectual and neurologic expressions, 3) gonadal effects--endocrine, reproductive, teratogenic and genetic, 4) dysfunction of other organs and structures, such as the thyroid, lung and heart and 5) oncogenesis. Many of these adversities are occasioned by radiation therapy, but chemotherapy also can be responsible for some long-term deleterious consequences. The results of combined chemo- and radiaton therapy are becoming better understood, and require further elucidation because earlier stages of the disease are being managed by combined chemo- and radiation therapy regimens.
1）儿童生长发育受损；2）中枢神经系统紊乱，包括心理、智力和神经方面的表现；3）性腺影响——内分泌、生殖、致畸和遗传方面；4）其他器官和结构功能障碍，如甲状腺、肺和心脏；5）肿瘤发生。这些不良后果许多是由放射治疗引起的，但化疗也可能导致一些长期有害后果。化疗和放疗联合治疗的结果正逐渐被更好地理解，由于疾病的早期阶段正通过化疗和放疗联合治疗方案进行管理，所以需要进一步阐明。
