From the Departments of Neurology.
Nuclear Medicine, Jena University Hospital, Jena, Germany.
Clin Nucl Med. 2022 Sep 1;47(9):830-831. doi: 10.1097/RLU.0000000000004313. Epub 2022 Jun 11.
Vitamin B12 deficiency may present with diverse symptoms, complicating the differential diagnosis. Extrapyramidal movement disorders, for instance, are a rare manifestation of vitamin B12 deficiency. MRI of the brain frequently remains without conclusive findings. However, 18 F-FDG PET/CT may reveal characteristic changes in the metabolism of the basal ganglia and thus contribute to an accurate diagnosis. We demonstrate the case of a woman with left-sided hemichoreatic movements due to vitamin B12 deficiency showing a contralateral putaminal hypermetabolism, which normalized after vitamin B12 supplementation, ruling out other deviating causes, particularly Huntington disease.
维生素 B12 缺乏症可能表现出多种症状，使鉴别诊断变得复杂。例如，锥体外系运动障碍是维生素 B12 缺乏症的罕见表现。大脑 MRI 常常没有明确的发现。然而，18 F-FDG PET/CT 可能会显示基底节代谢的特征性变化，从而有助于准确诊断。我们展示了一例因维生素 B12 缺乏引起左侧偏侧舞蹈症的病例，该患者对侧壳核代谢亢进，在补充维生素 B12 后恢复正常，排除了其他不同的原因，特别是亨廷顿病。
