Changes in chromosome patterns of murine lymphosarcoma LS/BL cells during long-term continuous irradiation in vivo.

The chromosome pattern of murine lymphosarcoma LS/BL and its changes during continuous exposure to ionizing radiation in vivo were studied. Absorbed dose rates (60Co) were 10 and 50 mGy/h. The hypodiploid sets with 39 chromosomes (73%) predominated in the control, unirradiated line. The continuously irradiated LS/BL-CI line exhibited insignificant changes in the modal chromosome number. The number of structural aberrations and sister chromatid exchanges was increased.