Department of Pathology, Konya City Hospital, University of Health Sciences, Konya, Turkey.
Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
J Cosmet Dermatol. 2022 Nov;21(11):6129-6133. doi: 10.1111/jocd.15155. Epub 2022 Jun 25.
Elevated platelet count (PC), mean platelet volume (MPV), and Platelet Mass Index (PMI) are reported in patients with psoriasis, while platelet activation is associated with psoriasis severity. Available studies examining the relationship between platelet activation markers and psoriasis have mostly focused on psoriasis area severity index. To the best of our knowledge, there is no study examining the relationship between histopathological features of a single psoriatic plaque and platelet activation. The present study examined the relationship between histomorphological findings obtained by morphometric analysis and psoriasis patients' PC, MPV, and PMI values.
Morphometric analysis was performed on hematoxylin and eosin-stained preparations of skin biopsies to measure minimum suprapapillary epidermis thickness (SPET ) and maximum epidermal thickness (ET ), maximum suprapapillary keratosis thickness (SPKT ), and maximum keratosis thickness (KT ). The relationship between PC, MPV, PMI, and morphometric skin biopsy outcomes was evaluated.
While an inverse correlation was found between SPETmin and PC and PMI in cases with psoriasis (p values = 0.015 and 0.005, r values = -0.238 and -0.271, respectively), no significant correlation was found between SPETmin and MPV (p value = 0.600, r value = -. 052). On the contrary, no significant correlation was found between SPKTmax, ETmax, and KTmax values and platelet parameters.
We assume that an increased risk of platelet activation-related diseases is expected in psoriasis patients displaying histopathological findings of suprapapillary thinning due to increased platelet activation; therefore, it may be beneficial to monitor these patients in terms of such risks.
银屑病患者的血小板计数（PC）、平均血小板体积（MPV）和血小板质量指数（PMI）升高，而血小板活化与银屑病严重程度相关。已有的研究大多集中在银屑病面积严重指数（PASI）上，检查血小板活化标志物与银屑病之间的关系。据我们所知，尚无研究检查单个银屑病斑块的组织病理学特征与血小板活化之间的关系。本研究检查了通过形态计量分析获得的组织形态学发现与银屑病患者 PC、MPV 和 PMI 值之间的关系。
对皮肤活检的苏木精和伊红染色标本进行形态计量分析，以测量最小的乳头上方表皮厚度（SPET）和最大表皮厚度（ET）、最大乳头上方角化厚度（SPKT）和最大角化厚度（KT）。评估 PC、MPV、PMI 与形态计量皮肤活检结果之间的关系。
在银屑病病例中，SPETmin 与 PC 和 PMI 呈负相关（p 值分别为 0.015 和 0.005，r 值分别为 -0.238 和 -0.271），而 SPETmin 与 MPV 之间无显著相关性（p 值为 0.600，r 值为 -.052）。相反，SPKTmax、ETmax 和 KTmax 值与血小板参数之间无显著相关性。
我们假设，由于血小板活化增加，显示出乳头上方变薄的组织病理学发现的银屑病患者，其血小板活化相关疾病的风险预计会增加；因此，监测这些患者的此类风险可能是有益的。
