Dhawan D, Mehta J, Mehta M, Kumar R, Chopra J S, Sharma R R
Digestion. 1987;36(2):84-90. doi: 10.1159/000199404.
The long-term effect of lithium treatment on the digestive and absorptive function has been investigated in male albino rats. The uptake of D-glucose, amino acids and activities of cellular and brush border enzymes were evaluated after every 3 months. Significantly increased uptake was observed in 6-month lithium-treated rats. The absorptive capacity (Vmax) for D-glucose increased significantly without alteration in the Michaelis constant. Activities of cellular, brush border membrane disaccharidase, leucine aminopeptidase and Na+,K+-ATPase enzymes were significantly augmented in 6-month lithium-treated animals. The elevation in sucrase activity may be due to induction of enzyme since only Vmax was increased in lithium-treated animals. The present biochemical alterations suggest that long-term lithium ingestion stimulates the small bowel digestive and absorptive functions.
已在雄性白化大鼠中研究了锂治疗对消化和吸收功能的长期影响。每3个月评估一次D-葡萄糖、氨基酸的摄取以及细胞和刷状缘酶的活性。在接受锂治疗6个月的大鼠中观察到摄取显著增加。D-葡萄糖的吸收能力（Vmax）显著增加，而米氏常数没有改变。在接受锂治疗6个月的动物中，细胞、刷状缘膜双糖酶、亮氨酸氨肽酶和Na +，K + -ATP酶的活性显著增强。蔗糖酶活性的升高可能是由于酶的诱导，因为在接受锂治疗的动物中只有Vmax增加。目前的生化改变表明，长期摄入锂会刺激小肠的消化和吸收功能。
