School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China.
J Colloid Interface Sci. 2022 Oct 15;624:734-746. doi: 10.1016/j.jcis.2022.06.009. Epub 2022 Jun 6.
Studies have shown that disulfiram (DSF) can combine with Cu to form bis(N, N-diethyldithiocarbamate) copper(II) complex (CuET) as antitumor drugs. However, there is insufficient endogenous Cu dose to eradicate cancer cells selectively. Inspired by the buffet, we use Cu doped hollow zeolitic imidazolate framework nanoparticles (HZIF) as the carrier and equipped with DSF and indocyanine green (ICG) and targeted by folic acid (FA) (D&I@HZIF-FA) to enhance DSF-based cancer therapy. D&I@HZIF-FA could effectively supply Cu by a buffet-style, assisting the "DSF-to-CuET" transformation in the tumor. Additionally, self-supply Cu could convert HO into ·OH by triggering a Fenton-like reaction for chemo-dynamic therapy, and ICG achieves photothermal therapy for tumors under laser irradiation. This work provides a buffet-style for Cu to make DSF a strong candidate for cancer treatment by combining chemotherapy, chemo-dynamic therapy, and photothermal therapy and inspires more research about its applications in tumor therapy.
研究表明，戒酒硫（DSF）可以与 Cu 结合形成双（N，N-二乙基二硫代氨基甲酸盐）铜（II）配合物（CuET）作为抗肿瘤药物。然而，体内缺乏足够的内源性 Cu 剂量来选择性地消灭癌细胞。受自助餐的启发，我们使用 Cu 掺杂的中空沸石咪唑骨架纳米粒子（HZIF）作为载体，并配备了 DSF 和吲哚菁绿（ICG），并通过叶酸（FA）靶向（D&I@HZIF-FA）以增强基于 DSF 的癌症治疗。D&I@HZIF-FA 可以通过自助餐式有效地提供 Cu，辅助肿瘤中的“DSF 到 CuET”转化。此外，自供应的 Cu 可以通过触发芬顿样反应将 HO 转化为·OH 用于化学动力学治疗，并且 ICG 在激光照射下实现肿瘤的光热治疗。这项工作为 Cu 提供了一种自助餐式的方式，使 DSF 成为治疗癌症的有力候选药物，结合了化疗、化学动力学治疗和光热治疗，并激发了更多关于其在肿瘤治疗中应用的研究。
