Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center, Campinas, Sao Paulo, Brazil.
Department of Physiology, University of California, San Francisco, CA, USA.
Trends Endocrinol Metab. 2022 Aug;33(8):587-599. doi: 10.1016/j.tem.2022.05.003. Epub 2022 Jun 10.
Owing to its unique capacity to clear macronutrients from circulation and use them to produce heat, thermogenic fat is capable of regulating glucose, lipids, and branched-chain amino acids (BCAA) circulatory levels. At the same time, its activity yields a higher energy expenditure, thereby conferring protection against cardiometabolic diseases. Our knowledge on the mechanisms of uptake and intracellular metabolism of such energy substrates into thermogenic fat has meaningfully evolved in recent years. This has allowed us to better understand how the thermogenic machinery processes those molecules to utilize them as substrates for heating up the body. Here, we discuss recent advances in the molecular and cellular regulatory process that governs the uptake and metabolism of such substrates within thermogenic fat.
由于其独特的清除循环中大分子营养素并利用它们产热的能力，生热脂肪能够调节葡萄糖、脂质和支链氨基酸（BCAA）的循环水平。同时，其活性导致更高的能量消耗，从而提供对心脏代谢疾病的保护。近年来，我们对生热脂肪吸收和细胞内代谢此类能量底物的机制的了解有了显著的发展。这使我们能够更好地理解生热机制如何处理这些分子，将它们用作加热身体的底物。在这里，我们讨论了控制生热脂肪中此类底物吸收和代谢的分子和细胞调节过程的最新进展。
