Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Obstetrics and Gynecology Department, Abadan University of Medical Sciences, Abadan, Iran.
Sci Rep. 2022 Jun 13;12(1):9815. doi: 10.1038/s41598-022-14112-1.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant women might affect both maternal and neonatal outcomes. Based on the inconsistency between the results of the previous studies and the lack of data about the possible vertical transmission of SARS-CoV-2, we designed the present study to investigate the maternal and perinatal outcomes in 182 Iranian pregnant women infected with COVID-19. Among 40 PCR tests conducted on neonatal throat samples, 11 tests were positive. Among the assessed women, 22 women needed ICU admission and 30 premature labors occurred. There were significant associations between ICU admission and many parameters such as the presence of dyspnea (P < 0.001), COVID-19-related CT scan findings (P = 0.003), need for a ventilator (P < 0.001), and low O saturation (P < 0.001), all of which indicate the critical situation of patients. Notably, the cause of delivery was significantly different in both groups, with labor pain and fetal distress being the most frequent causes of delivery in non-ICU and ICU-admitted patients, respectively. Moreover, delivery route (P = 0.003), frequencies of IUGR (P = 0.042), neonatal death (P = 0.008) and asphyxia (P = 0.016), Apgar score (P = 0.003), and gestational age at delivery (P = 0.009) have been associated with ICU admission. The present investigation exhibits association between the critical situation of pregnant women affected with COVID-19 and some adverse neonatal outcomes.
感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）可能会影响孕妇和新生儿的结局。基于之前研究结果的不一致以及关于 SARS-CoV-2 可能垂直传播的缺乏数据，我们设计了本研究来调查 182 名感染 COVID-19 的伊朗孕妇的母婴结局。在对新生儿咽喉样本进行的 40 次 PCR 检测中，有 11 次检测呈阳性。在所评估的妇女中，有 22 名妇女需要入住 ICU，有 30 名早产。ICU 入住与许多参数之间存在显著关联，如呼吸困难的存在（P<0.001）、COVID-19 相关 CT 扫描结果（P=0.003）、需要呼吸机（P<0.001）和低 O 饱和度（P<0.001），所有这些都表明患者的危急情况。值得注意的是，两组的分娩原因明显不同，劳动疼痛和胎儿窘迫分别是非 ICU 和 ICU 入院患者的最常见分娩原因。此外，分娩方式（P=0.003）、IUGR 频率（P=0.042）、新生儿死亡（P=0.008）和窒息（P=0.016）、阿普加评分（P=0.003）和分娩时的胎龄（P=0.009）与 ICU 入住相关。本研究表明，COVID-19 感染孕妇的危急情况与一些不良新生儿结局相关。
