Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri, Nagano, 399-0781, Japan.
Department of Hard Tissue Research, Graduate School of Oral Medicine, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri, Nagano, 399-0781, Japan.
J Bone Miner Metab. 2022 Sep;40(5):773-781. doi: 10.1007/s00774-022-01343-5. Epub 2022 Jun 13.
Little is known about whether substances inducing tissue protein degeneration in the oral cavity are associated with the number of teeth present in postmenopausal women. We sought to investigate the association of urinary pentosidine and serum homocysteine levels with the number of teeth and subsequent tooth loss in Japanese postmenopausal women.
Among participants in the Nagano Cohort Study, 785 postmenopausal women (mean age, 68.1 years) participated in the present study. The number of teeth was re-counted at the time of follow-up in 610 women. Poisson regression analysis was used to investigate differences in the number of teeth among quartiles of pentosidine or homocysteine, adjusting for covariates that correlated with the number of teeth. A Cox proportional hazard model was used to evaluate the association of subsequent tooth loss with pentosidine or homocysteine levels.
Pentosidine quartiles were not associated with the number of teeth at baseline. Participants in the highest homocysteine quartile had significantly fewer teeth at baseline than those in the third and lowest quartiles (p < 0.001 for both). Those in the second quartile had fewer teeth than those in the third (p = 0.001) and lowest (p < 0.001) quartiles. An increased risk of tooth loss during follow-up was significantly associated with higher urinary pentosidine (hazard ratio = 1.073 for 10 pmol/mgCre; p = 0.001).
Postmenopausal women with higher homocysteine levels had fewer teeth at baseline. A higher pentosidine concentration increased the risk of subsequent tooth loss. High pentosidine or homocysteine concentrations may be associated with tooth loss in postmenopausal women.
目前对于诱导口腔组织蛋白变性的物质是否与绝经后妇女的牙齿数量有关知之甚少。我们旨在研究尿戊糖和血清同型半胱氨酸水平与日本绝经后妇女的牙齿数量及其随后的牙齿脱落之间的关系。
在长野队列研究的参与者中，785 名绝经后妇女（平均年龄 68.1 岁）参加了本研究。在 610 名女性随访时重新计数了牙齿数量。使用泊松回归分析调查了戊糖或同型半胱氨酸四分位数之间牙齿数量的差异，并调整了与牙齿数量相关的协变量。使用 Cox 比例风险模型评估了戊糖或同型半胱氨酸水平与随后牙齿脱落的关系。
戊糖四分位数与基线时的牙齿数量无关。同型半胱氨酸四分位数最高的参与者的牙齿数量明显少于第三和最低四分位数的参与者（两者均 p < 0.001）。第二四分位数的牙齿数量少于第三（p = 0.001）和最低（p < 0.001）四分位数。随访期间牙齿脱落的风险增加与尿戊糖水平升高显著相关（10 pmol/mgCre 时的危险比为 1.073；p = 0.001）。
同型半胱氨酸水平较高的绝经后妇女的牙齿数量较少。较高的戊糖浓度增加了随后牙齿脱落的风险。高戊糖或同型半胱氨酸浓度可能与绝经后妇女的牙齿脱落有关。
