西咪替丁对大鼠生殖器官的一些影响。
Some effects of cimetidine on the reproductive organs of rats.
作者信息
Pereira O C
出版信息
Gen Pharmacol. 1987;18(2):197-9. doi: 10.1016/0306-3623(87)90250-3.
PMID:3569846
Abstract
The development of genital organs of rats chronically treated with cimetidine showed that the drug may present anti-androgenic activity. This treatment did not alter the sensitivity of vas deferens to noradrenaline, but increased their sensitivity to BaCl2. In the male reproductive system, cimetidine must have peripheral actions apart from the central ones observed after chronic treatment.
摘要
长期用西咪替丁治疗的大鼠生殖器官发育情况表明，该药物可能具有抗雄激素活性。这种治疗并未改变输精管对去甲肾上腺素的敏感性，但增加了其对氯化钡的敏感性。在雄性生殖系统中，西咪替丁除了在长期治疗后观察到的中枢作用外，必定还具有外周作用。
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