Kunz Fabian, Sendag Sait, Yildiz Mehmet, Failing Klaus, Wehrend Axel
Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals with Ambulatory Service, Justus-Liebig-University, Giessen, Germany.
Clinic for Veterinary Obstetrics and Gynecology, University of Van YYÜ, Van, Turkey.
Vet World. 2022 Apr;15(4):981-985. doi: 10.14202/vetworld.2022.981-985. Epub 2022 Apr 19.
Calves have increased morbidity and mortality rates after dystocia. One cause is pain during birth, which reduces their colostrum intake. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) may break this causality. This study aimed to determine the consequences of a single administration of the NSAID meloxicam to dystocia calves after birth.
Fifty Holstein-Friesian calves born with dystocia from four dairy cattle farms were included in this study. The animals were randomized into two groups. The animals in Group I (n=25, treatment group) received subcutaneous 0.5 mg meloxicam/kg body weight 2-8 h after birth. The animals in Group II (n=25, control group) received a control substance (Amynin, bovine infusion solution, Merial) with the same volume. The newborn calves were clinically examined on the 1 and 10 days of life. The information regarding the days in between was gathered by questioning the farmer.
There was a significant difference (p=0.04) only in calves with thin, mushy fecal consistency on the 10 day in the treatment group compared with the control group. Moreover, meloxicam had no effect on dystocia calves.
Since NSAID administration did not produce a significant clinical effect, its necessity is questionable. Further studies should examine how modifying its application time would have an effect. The primary indicators of well-being, such as pain indicators in the blood, were not measured; however, these should be considered in subsequent studies.
难产犊牛的发病率和死亡率较高。原因之一是分娩时的疼痛,这会减少它们初乳的摄入量。非甾体抗炎药(NSAIDs)的使用可能会打破这种因果关系。本研究旨在确定出生后给难产犊牛单次注射美洛昔康的效果。
本研究纳入了来自四个奶牛场的50头因难产出生的荷斯坦 - 弗里生犊牛。将这些动物随机分为两组。第一组(n = 25,治疗组)的动物在出生后2 - 8小时皮下注射0.5毫克美洛昔康/千克体重。第二组(n = 25,对照组)的动物接受相同体积的对照物质(阿明宁,牛用输液溶液,梅里亚公司)。在出生后第1天和第10天对新生犊牛进行临床检查。通过询问养殖户收集其间的信息。
与对照组相比,仅在出生后第10天,治疗组中粪便质地稀薄、呈糊状的犊牛存在显著差异(p = 0.04)。此外,美洛昔康对难产犊牛没有影响。
由于使用NSAIDs未产生显著的临床效果,其必要性值得怀疑。进一步的研究应考察改变其应用时间会产生怎样的影响。本研究未测量诸如血液中疼痛指标等福利的主要指标;然而,后续研究应予以考虑。